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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Evidence for a lactate pool in the rat brain that is not used as an energy supply under normoglycemic conditions.
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Evidence for a lactate pool in the rat brain that is not used as an energy supply under normoglycemic conditions.

机译：在正常血糖条件下，大鼠大脑中的乳酸池没有用作能量供应的证据。

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摘要

Lactate derived from glucose can serve as an energy source in the brain. However, it is not certain how much lactate, directly taken from the blood circulation, may replace glucose as an energy source. This study aimed to estimate the uptake, release, and utilization of lactate entering the brain from the blood circulation. The change in cerebral venous-arterial glucose and lactate differences after lactate infusions in the anesthetized rat were measured. Ultrafiltration probes were placed in the aorta and in the jugular vein, and connected to a flow injection analysis system with biosensors for glucose and lactate. Measurements were taken every minute. Lactate efflux was observed at baseline, whereas an influx of lactate was seen during lactate infusion. Immediately after the infusion there was a net efflux of lactate from the brain. The results suggest that the majority of lactate moving into the brain is not used as an energy substrate, and that lactate does not replace glucose as an energy source. Instead, the authors propose the concept of a lactate pool in the brain that can be filled and emptied in accordance with the blood lactate concentration, but which is not used as an energy supply for cerebral metabolism.
机译：葡萄糖中的乳酸可作为大脑的能量来源。但是，尚不确定直接从血液循环中摄取多少乳酸可以代替葡萄糖作为能源。这项研究旨在评估乳酸从血液循环进入大脑的吸收，释放和利用。测量麻醉大鼠输注乳酸后脑静脉动脉葡萄糖和乳酸差异的变化。将超滤探头放置在主动脉和颈静脉中，并与带有葡萄糖和乳酸生物传感器的流动注射分析系统连接。每分钟进行一次测量。在基线时观察到乳酸流出，而在输注乳酸期间观察到乳酸流入。输液后立即从大脑中净流出乳酸。结果表明，大多数进入大脑的乳酸盐不被用作能量底物，并且乳酸盐不能代替葡萄糖作为能源。相反，作者提出了大脑中的乳酸池的概念，该池可以根据血液中的乳酸浓度进行填充和排空，但不能用作脑代谢的能量供应。

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