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Estimation of component and parameter distributions in spectral analysis.

机译:光谱分析中组分和参数分布的估计。

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摘要

A method is presented for estimating the distributions of the components and parameters determined with spectral analysis when it is applied to a single data set. The method uses bootstrap resampling to simulate the effect of noise on the computed spectrum and to correct for possible bias in the estimates. A number of bootstrap procedures are reviewed, and one is selected for application to the kinetic analysis of positron emission tomography dynamic studies. The technique is shown to require minimal assumptions about noise in the measurements, and its small sample properties are established through Monte-Carlo simulations. The advantages and limitations of spectral analysis with bootstrap resampling for deriving inferences for tracer kinetic modeling are illustrated through sample analyses of time-activity curves for [18F]fluorodeoxyglucose and [15O]-labeled water.
机译:提出了一种方法,用于估算将光谱分析应用于单个数据集时确定的组件和参数的分布。该方法使用自举重采样来模拟噪声对计算频谱的影响,并校正估计中可能存在的偏差。审查了许多自举程序,并选择了一种用于正电子发射断层扫描动力学研究的动力学分析。这项技术显示出对测量噪声的最小假设,并且它的小样本属性是通过蒙特卡洛仿真建立的。通过对[18F]氟脱氧葡萄糖和[15O]标记的水的时间-活性曲线进行样本分析,说明了使用自举重采样进行频谱分析以得出示踪剂动力学模型推论的优势和局限性。

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