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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat.
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Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat.

机译：在大鼠中静脉内注射乳酸后模拟脑动静脉乳酸动力学。

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摘要

Venous-arterial lactate differences across the brain during lactate infusion in rats were studied, and the fate of lactate was described with a mathematical model that includes both cerebral and extracerebral kinetics. Ultrafiltration was used to sample continuously and simultaneously arterial and venous blood. Subsequent application of flow injection analysis and biosensors allowed the measurement of glucose and lactate concentrations every minute. Because of the high temporal resolution, arteriovenous lactate kinetics could be modeled in individual experiments. The existence of both a cerebral lactate sink and a lactate exchangeable compartment, representing approximately 24% of brain volume, was thus modeled.
机译：研究了在大鼠输注乳酸期间大脑中静脉-动脉乳酸的差异，并用包括脑动力学和脑外动力学在内的数学模型描述了乳酸的命运。超滤用于连续不断地采集动脉血和静脉血。随后应用流动注射分析和生物传感器可以每分钟测量一次葡萄糖和乳酸浓度。由于时间分辨率高，因此可以在单个实验中模拟动静脉乳酸动力学。因此，模拟了大脑乳酸池和乳酸交换室的存在，它们代表大脑体积的大约24％。

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