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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Effects of hypothermia on energy metabolism in Mammalian central nervous system.
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Effects of hypothermia on energy metabolism in Mammalian central nervous system.

机译：亚低温对哺乳动物中枢神经系统能量代谢的影响。

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摘要

This review analyzes, in some depth, results of studies on the effect of lowered temperatures on cerebral energy metabolism in animals under normal conditions and in some selected pathologic situations. In sedated and paralyzed mammals, acute uncomplicated 0.5- to 3-h hypothermia decreases the global cerebral metabolic rate for glucose (CMR(glc)) and oxygen (CMRo(2)) but maintains a slightly better energy level, which indicates that ATP breakdown is reduced more than its synthesis. Intracellular alkalinization stimulates glycolysis and independently enhances energy generation. Lowering of temperature during hypoxia-ischemia slows the rate of glucose, phosphocreatine, and ATP breakdown and lactate and inorganic phosphate formation, and improves recovery of energetic parameters during reperfusion. Mild hypothermia of 12 to 24-h duration after normothermic hypoxic-ischemic insults seems to prevent or ameliorate secondary failures in energy parameters. The authors conclude that lowered head temperatures help to protect and maintain normal CNS function by preserving brain ATP supply and level. Hypothermia may thus prove a promising avenue in the treatment of stroke and trauma and, in particular, of perinatal brain injury.
机译：这篇综述深入地分析了在正常条件下和某些特定病理情况下，温度降低对动物脑能量代谢的影响的研究结果。在镇静和瘫痪的哺乳动物中，急性简单的0.5至3小时的体温过低会降低葡萄糖（CMR（glc））和氧气（CMRo（2））的总体脑代谢率，但能维持略高的能量水平，这表明ATP分解减少的程度超过其综合程度。细胞内碱化刺激糖酵解并独立增强能量产生。缺氧缺血期间温度的降低会减慢葡萄糖，磷酸肌酸和ATP分解的速度以及乳酸和无机磷酸盐的形成，并改善再灌注过程中能量参数的恢复。在常温低氧缺血性损伤后持续12至24小时的轻度低温似乎可以预防或缓解继发性的能量参数衰竭。作者得出的结论是，较低的头部温度可通过保持大脑ATP的供应和水平来帮助保护和维持正常的中枢神经系统功能。因此，体温过低可能被证明是治疗中风和创伤，尤其是围产期脑损伤的有前途的途径。

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