...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Spontaneous low-frequency oscillations decline in the aging brain.
【24h】

Spontaneous low-frequency oscillations decline in the aging brain.

机译：自发性低频振荡在衰老的大脑中下降。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is well known that aging leads to a degeneration of the vascular system. Hence, one may hypothesize that spontaneous oscillations decrease in the cerebral microvasculature with aging. Accordingly, the authors investigated the age dependency of spontaneous oscillations in the visual cortex during rest and functional activation. Functional near-infrared spectroscopy was used because it is particularly sensitive to the microvasculature. Visual stimulation led to an increase of oxyhemoglobin, total hemoglobin, and a decrease of deoxyhemoglobin, without any influence of age. Peaks of normalized power spectral density were detected for spontaneous low-frequency (0.07 to 0.11 Hz) and very-low-frequency (0.01 to 0.05 Hz) oscillations, with a higher amplitude for oxyhemoglobin than for deoxyhemoglobin. Spontaneous low-frequency oscillations of oxyhemoglobin and deoxyhemoglobin declined strongly with aging during both rest and visual stimulation. Reduction of spontaneous low-frequency oscillations might indicate a declining spontaneous activity in microvascular smooth muscle cells, in conjunction with an increased vessel stiffness with aging.
机译：众所周知，衰老会导致血管系统退化。因此，可以假设随着衰老，大脑微脉管系统的自发振荡减少。因此，作者研究了休息和功能激活期间视皮层自发振荡的年龄依赖性。使用功能性近红外光谱法是因为它对微脉管系统特别敏感。视觉刺激导致氧合血红蛋白增加，总血红蛋白和脱氧血红蛋白减少，而不受年龄的影响。对于自发的低频（0.07至0.11 Hz）和非常低频的（0.01至0.05 Hz）振荡，检测到归一化功率谱密度的峰值，氧合血红蛋白的振幅比脱氧血红蛋白的振幅高。在休息和视觉刺激下，氧合血红蛋白和脱氧血红蛋白的自发低频振荡随衰老而强烈下降。自发性低频振荡的减少可能表明微血管平滑肌细胞的自发性活动下降，并伴随着衰老而增加的血管刚度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号