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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >PET functional imaging of deep brain stimulation in movement disorders and psychiatry.
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PET functional imaging of deep brain stimulation in movement disorders and psychiatry.

机译：在运动障碍和精神病学方面深部脑刺激的PET功能成像。

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摘要

Deep brain stimulation (DBS) represents a major advance in the treatment of various severe movement disorders or neuropsychiatric diseases. Our understanding of the mechanism of action of this surgical treatment has greatly benefited from functional imaging studies. Most of these studies have been conducted in patients with Parkinson's disease (PD) treated by bilateral subthalamic nucleus (STN) stimulation. These studies have notably underlined the fact that STN stimulation influences motor, limbic, or associative cortical-subcortical loops in various (sometimes contradictory) ways. We present an up-to-date review of the information provided by functional imaging studies in surgery for PD, dystonia, tremor, as well as in psychiatric disorders such as depression or obsessive-compulsive disorder. On the basis of this information, proposed mechanisms of action of DBS are discussed, as well as the need for additional approaches such as improved anatomical localization of the contact used for stimulation or a better understanding of the electrical distribution around the electrode.
机译：深部脑刺激（DBS）代表了在治疗各种严重运动障碍或神经精神疾病方面的重大进展。功能成像研究使我们对这种手术治疗的作用机理的了解大大受益。这些研究大多数是在通过双边丘脑底核（STN）刺激治疗的帕金森氏病（PD）患者中进行的。这些研究特别强调了一个事实，即STN刺激以各种（有时是相互矛盾的）方式影响运动，边缘或相关的皮下皮层循环。我们对功能性影像学研究在PD，肌张力障碍，震颤以及精神疾病（如抑郁症或强迫症）中提供的信息进行了最新综述。基于该信息，讨论了提议的DBS作用机理，以及对其他方法的需求，例如对用于刺激的接触点的解剖位置进行了改进，或者更好地了解了电极周围的电分布。

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