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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus.
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Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus.

机译：慢性脑积水后尾状核中血管内皮生长因子受体2与血管密度的分离。

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摘要

Chronic hydrocephalus (CH) is characterized by the presence of ventricular enlargement, decreased cerebral blood flow (CBF), and brain tissue oxygen delivery. Although the underlying pathophysiological role of vascular endothelial growth factor (VEGF) is not clear, ischemic-hypoxic events in CH are known to trigger its release. Previously, we have shown increased VEGF receptor-2 (VEGFR-2) and blood vessel density (BVd) in the hippocampus after CH. We investigated changes in neuronal and glial VEGFR-2 density and BVd in the caudate nucleus in an experimental model of CH. Animals with CH were divided into short term (ST, 2 to 4 weeks) and long term (LT, 12 to 16 weeks) and were compared with surgical controls (SCs, 12 to 16 weeks). The cellular and BVds were estimated using immunohistochemical and stereological counting methods. Overall, percentage (%)VEGFR-2 neurons were approximately two times greater in CH (ST, LT) than in SC. By comparison, glial cell %VEGFR-2 was greater by 10% to 17% in ST and 4% to 11% lower in LT compared with that in SC. Blood vessel density was significantly lower in CH than in SC in the superficial caudate. Changes in cerebrospinal fluid ventricular volume and pressure, as well as in CBF did not correlate with either VEGFR-2 or BVd. These observed findings suggest that destructive forces may outweigh angiogenic forces and possibly show a disassociation between VEGFR-2 and BV expressions.
机译：慢性脑积水（CH）的特征是存在心室扩大，脑血流量（CBF）减少和脑组织氧输送。尽管尚不清楚血管内皮生长因子（VEGF）的潜在病理生理作用，但已知CH中的缺血缺氧事件会触发其释放。以前，我们已经显示CH后海马中的VEGF受体2（VEGFR-2）和血管密度（BVd）增加。我们研究了CH实验模型中尾状核中神经元和神经胶质VEGFR-2密度和BVd的变化。将患有CH的动物分为短期（ST，2-4周）和长期（LT，12-16周），并与手术对照组（SC，12-16周）进行比较。使用免疫组织化学和体视学计数方法估计细胞和BVds。总体而言，CH（ST，LT）中VEGFR-2神经元的百分比（％）大约比SC大两倍。相比之下，与SC相比，ST中胶质细胞％VEGFR-2的含量高10％至17％，而LT的含量低4％至11％。 CH的血管密度显着低于SC的浅尾状尾。脑脊液心室容积和压力以及CBF的变化与VEGFR-2或BVd均不相关。这些观察到的结果表明，破坏力可能大于血管生成力，并且可能显示VEGFR-2和BV表达之间没有关联。

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