...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke.
【24h】

High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke.

机译：急性缺血性中风中高谷氨酸草酰乙酸转氨酶水平与良好的功能预后相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The capacity of the blood enzyme glutamate oxaloacetate transaminase (GOT) to remove glutamate from the brain by means of blood glutamate degradation has been shown in experimental models to be an efficient and novel neuroprotective tool against ischemic stroke; however, the beneficial effects of this enzyme should be tested in patients with stroke to validate these results. This study aims to investigate the association of GOT levels in blood with clinical outcome in patients with acute ischemic stroke. In two clinical independent studies, we found that patients with poor outcome show higher glutamate and lower GOT levels in blood at the time of admission. Lower GOT levels and higher glutamate levels were independently associated with poorer functional outcome at 3 months and higher infarct volume. These findings show a clear association between high blood glutamate levels and worse outcome and vice versa for GOT, presumably explained by the capacity of this enzyme to metabolize blood glutamate.
机译：实验模型表明，血液酶谷氨酸草酰乙酸转氨酶（GOT）通过血液谷氨酸降解从大脑清除谷氨酸的能力是一种有效的新型抗缺血性中风的神经保护工具。然而，该酶的有益作用应在中风患者中进行测试以验证这些结果。这项研究旨在探讨急性缺血性中风患者血液中GOT水平与临床预后的关系。在两项临床独立研究中，我们发现结局较差的患者在入院时表现出较高的谷氨酸和较低的GOT水平。较低的GOT水平和较高的谷氨酸水平独立地与3个月时功能预后较差和梗死体积增加有关。这些发现表明，高谷氨酸水平和较差的结果之间存在明显的联系，反之亦然，GOT反之亦然，这可能是由于该酶代谢谷氨酸的能力所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号