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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation.
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Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation.

机译：大鼠脑缺血-再灌注损伤-3T MRI研究双相血脑屏障开放和水肿形成动态。

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摘要

Serial magnetic resonance imaging (MRI) was performed to investigate the temporal and spatial relationship between the biphasic nature of blood-brain barrier (BBB) opening and, in parallel, edema formation after ischemia-reperfusion (I/R) injury in rats. T(2)-weighted imaging combined with T(2)-relaxometry, mainly for edema assessment, was performed at 1 h after ischemia, after reperfusion, and at 4, 24 and 48 h after reperfusion. T(1)-weighted imaging was performed before and after gadolinium contrast at the last three time points to assess BBB integrity. The biphasic course of BBB opening with a significant reduction in BBB permeability at 24 h after reperfusion, associated with a progressive expansion of leaky BBB volume, was accompanied by a peak ipsilateral edema formation. In addition, at 4 h after reperfusion, edema formation could also be detected at the contralateral striatum as determined by the elevated T(2)-values that persisted to varying degrees, indicative of widespread effects of I/R injury. The observations of this study may indicate a dynamic temporal shift in the mechanisms responsible for biphasic BBB permeability changes, with complex relations to edema formation. Stroke therapy aimed at vasogenic edema and drug delivery for neuroprotection may also be guided according to the functional status of the BBB, and these findings have to be confirmed in human stroke.
机译：进行了串联磁共振成像（MRI），以研究血脑屏障（BBB）开口的两相性质与缺血/再灌注（I / R）损伤后水肿形成之间的时间和空间关系。 T（2）加权成像结合T（2）松弛测量，主要用于水肿评估，在缺血后1小时，再灌注后以及再灌注后4、24和48小时进行。在最后三个时间点，在contrast对比之前和之后进行T（1）加权成像，以评估BBB完整性。 BBB开放的双相过程，再灌注后24 h BBB通透性显着降低，与漏泄BBB量的逐渐扩大相关，同侧水肿形成高峰。另外，在再灌注后4小时，对侧纹状体也可检测到水肿形成，这是由持续程度不同的升高的T（2）值确定的，表明I / R损伤的广泛影响。这项研究的观察结果可能表明，导致双相BBB通透性变化的机制发生了动态的时间变化，与水肿形成有复杂关系。还可以根据BBB的功能状态来指导针对血管源性水肿和神经保护药物的中风治疗，这些发现必须在人中风中得到证实。

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