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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.
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Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.

机译：青少年脑外伤会导致长期的血管周基质变化以及淀粉样β积累。

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摘要

In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (Aβ) accumulation. We investigated NVU changes for up to 6 months in a rat jTBI model, with a focus on the efflux protein P-glycoprotein (P-gp) and on the basement membrane proteins perlecan and fibronectin, all known to be involved in Aβ clearance. Rodent-Aβ staining is present and increased after jTBI around cerebral blood microvessels, and the diameter of those is decreased by 25% and 34% at 2 and 6 months, respectively, without significant angiogenesis. P-glycoprotein staining in endothelium is decreased by 22% and parallels an increase of perlecan and fibronectin staining around cerebral blood vessels. Altogether, these results strongly suggest that the emergence of long-term behavioral dysfunctions observed in rodent jTBI may be related to endothelial remodeling at the blood-brain barrier alongside vascular dysfunction and altered Aβ trafficking. This study shows that it is important to consider jTBI as a vascular disorder with long-term consequences on cognitive functions.
机译：在我们的青少年外伤性脑损伤（jTBI）模型中，在外伤后6个月内观察到认知功能障碍的出现。在这里，我们假设早期的脑损伤会导致神经血管单位（NVU）的变化，该变化与淀粉样蛋白（Aβ）的积累有关。我们在大鼠jTBI模型中调查了长达6个月的NVU变化，重点是外排蛋白P-糖蛋白（P-gp）以及基底膜蛋白perlecan和纤连蛋白，所有这些蛋白均与Aβ清除有关。在大脑血液微血管周围进行jTBI后，啮齿类动物Aβ染色存在并增加，并且它们的直径分别在2和6个月时分别降低了25％和34％，而没有明显的血管生成。内皮中的P-糖蛋白染色减少了22％，与脑血管周围的Perlecan和纤连蛋白染色增加平行。总之，这些结果强烈表明，在啮齿动物jTBI中观察到的长期行为功能障碍的出现可能与血脑屏障的内皮重塑以及血管功能障碍和Aβ转运改变有关。这项研究表明，将jTBI视为对认知功能具有长期影响的血管疾病非常重要。

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