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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Transient increase of fractional anisotropy in reversible vasogenic edema
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Transient increase of fractional anisotropy in reversible vasogenic edema

机译：可逆性血管源性水肿的分数各向异性的短暂增加

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摘要

Brain vasogenic edema, involving disruption of the blood-brain barrier, is a common pathological condition in several neurological diseases, with a heterogeneous prognosis. It is sometimes reversible, as in posterior reversible encephalopathy syndrome, but often irreversible and our current clinical tools are insufficient to reveal its reversibility. Here, we show that increased fractional anisotropy in magnetic resonance imaging is associated with the reversibility of vasogenic edema. Spontaneously, hypertensive rats-stroke prone demonstrated posterior reversible encephalopathy syndrome-like acute encephalopathy in response to high-dose cyclosporine A treatment; the deteriorating neurological symptoms and worsening scores in behavioral tests, which were seen in acute phase, dissappered after recovery by cessation of cyclosporine A. In the acute phase of encephalopathy, the fractional anisotropy and apparent diffusion coefficient increased in areas with IgG leakage. This increase of fractional anisotropy occurred in the absence of demyelination: fluid leakage into the myelinated space increased the axial, but not the radial, diffusivity, resulting in the increased fractional anisotropy. This increased fractional anisotropy returned to pre-encephalopathy values in the recovery phase. Our results highlight the importance of the fractional anisotropy increase as a marker for the reversibility of brain edema, which can delineate the brain areas for which recovery is possible.
机译：脑血管源性水肿，包括血脑屏障的破坏，是几种神经系统疾病的常见病理状况，预后不同。它有时是可逆的，如后可逆性脑病综合征，但通常是不可逆的，我们目前的临床工具不足以揭示其可逆性。在这里，我们显示磁共振成像中分数各向异性的增加与血管性水肿的可逆性有关。自发地，高血压大鼠中风倾向表现为对大剂量环孢霉素A治疗的后可逆性脑病综合征样急性脑病。在行为测试中观察到的恶化的神经系统症状和评分恶化（在急性期可见），在恢复后因停止环孢霉素A而消失。在脑病的急性期，IgG漏出区域的部分各向异性和表观扩散系数增加。分数各向异性的这种增加是在没有脱髓鞘的情况下发生的：流体渗入有髓鞘的空间会增加轴向扩散率，而不是径向扩散率，导致分数各向异性增加。在恢复阶段，这种增加的分数各向异性返回到脑病前的值。我们的研究结果强调了分数各向异性的增加作为脑水肿可逆性的标志的重要性，脑水肿可描绘出可能恢复的脑区域。

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