...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Method for rapid MRI quantification of global cerebral metabolic rate of oxygen
【24h】

Method for rapid MRI quantification of global cerebral metabolic rate of oxygen

机译：快速定量脑总氧代谢率的MRI方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A recently reported quantitative magnetic resonance imaging (MRI) method denoted OxFlow has been shown to be able to quantify whole-brain cerebral metabolic rate of oxygen (CMRO2) by simultaneously measuring oxygen saturation (SvO2) in the superior sagittal sinus and cerebral blood flow (CBF) in the arteries feeding the brain in 30 seconds, which is adequate for measurement at baseline but not necessarily in response to neuronal activation. Here, we present an accelerated version of the method (referred to as F-OxFlow) that quantifies CMRO2 in 8 seconds scan time under full retention of the parent method's capabilities and compared it with its predecessor at baseline in 10 healthy subjects. Results indicate excellent agreement between both sequences, with mean bias of 2.2% (P = 0.18, two-tailed t-test), 3.4% (P = 0.08, two-tailed t-test), and 2.0% (P = 0.56, two-tailed t-test) for SvO2, CBF, and CMRO2, respectively. F-OxFlow's potential to monitor dynamic changes in SvO2, CBF, and CMRO2 is illustrated in a paradigm of volitional apnea applied to five of the study subjects. The sequence captured an average increase in SvO2, CBF, and CMRO2 of 10.1 +/- 2.5%, 43.2 +/- 9.2%, and 7.1 +/- 2.2%, respectively, in good agreement with literature values. The method may therefore be suited for monitoring alterations in CBF and SvO2 in response to neurovascular stimuli.
机译：最近报道的一种称为OxFlow的定量磁共振成像（MRI）方法已被证明能够通过同时测量上矢状窦和大脑血流中的氧饱和度（SvO2）来量化全脑大脑氧代谢率（CMRO2）（ CBF）在30秒钟内供给大脑的动脉中，这足以进行基线测量，但不一定响应神经元激活。在这里，我们介绍了该方法的加速版本（称为F-OxFlow），该方法在完全保留父方法的功能的情况下，在8秒的扫描时间内对CMRO2进行了定量，并将其与10位健康受试者的基线水平进行了比较。结果表明两个序列之间的一致性极好，平均偏差分别为2.2％（P = 0.18，两尾t检验），3.4％（P = 0.08，两尾t检验）和2.0％（P = 0.56，分别针对SvO2，CBF和CMRO2进行两尾t检验）。 F-OxFlow监测SvO2，CBF和CMRO2动态变化的潜力在对五个研究对象的自主呼吸暂停范例中得到了说明。该序列捕获的SvO2，CBF和CMRO2平均增加分别为10.1 +/- 2.5％，43.2 +/- 9.2％和7.1 +/- 2.2％，与文献值非常吻合。因此，该方法可能适合于监测响应神经血管刺激的CBF和SvO2的变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号