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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard
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A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard

机译：一种基准测试工具，可根据DWI标准评估计算机断层扫描灌注梗死核心预测

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摘要

Differences in research methodology have hampered the optimization of Computer Tomography Perfusion (CTP) for identification of the ischemic core. We aim to optimize CTP core identification using a novel benchmarking tool. The benchmarking tool consists of an imaging library and a statistical analysis algorithm to evaluate the performance of CTP. The tool was used to optimize and evaluate an in-house developed CTP-software algorithm. Imaging data of 103 acute stroke patients were included in the benchmarking tool. Median time from stroke onset to CT was 185min (IQR 180-238), and the median time between completion of CT and start of MRI was 36min (IQR 25-79). Volumetric accuracy of the CTP-ROIs was optimal at an rCBF threshold of <38%; at this threshold, the mean difference was 0.3ml (SD 19.8ml), the mean absolute difference was 14.3 (SD 13.7) ml, and CTP was 67% sensitive and 87% specific for identification of DWI positive tissue voxels. The benchmarking tool can play an important role in optimizing CTP software as it provides investigators with a novel method to directly compare the performance of alternative CTP software packages.
机译：研究方法的差异阻碍了计算机断层扫描灌注（CTP）识别缺血核心的优化。我们旨在使用一种新颖的基准测试工具来优化CTP核心识别。基准测试工具包括一个影像库和一个统计分析算法，用于评估CTP的性能。该工具用于优化和评估内部开发的CTP软件算法。标杆工具中包括103例急性中风患者的影像数据。从卒中发作到CT的中位时间为185分钟（IQR 180-238），从CT完成到开始MRI的中位时间为36min（IQR 25-79）。 CTP-ROIs的体积精度在rCBF阈值<38％时最佳。在此阈值时，平均差为0.3ml（SD 19.8ml），平均绝对差为14.3（SD 13.7）ml，CTP敏感性为67％，特异性为DWI阳性组织体素的87％。基准测试工具在优化CTP软件方面可以发挥重要作用，因为它为研究人员提供了一种直接比较其他CTP软件包性能的新颖方法。

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