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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Quantitative comparison of functional contrast from BOLD-weighted spin-echo and gradient-echo echoplanar imaging at 1.5 Tesla and H2 15O PET in the whole brain.
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Quantitative comparison of functional contrast from BOLD-weighted spin-echo and gradient-echo echoplanar imaging at 1.5 Tesla and H2 15O PET in the whole brain.

机译：在全脑中以1.5 Tesla和H2 15O PET进行BOLD加权自旋回波和梯度回波回波平面成像的功能对比的定量比较。

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摘要

Spin-echo and gradient-echo echoplanar functional magnetic resonance imaging (fMRI) studies at 1.5 Tesla (T) were used to obtain blood oxygenation level-dependent (BOLD) contrast images of the whole brain in seven strongly right-handed women during execution of a complex motor task. Five subjects underwent subsequent H215O positron emission tomography (PET) studies while performing the same task. Group-averaged results for changes in the MRI relaxation rates R2* and R2 at 1.5T in response to neuronal activation in nine cortical, subcortical, and cerebellar motor regions are reported. Results for each method are grouped according to tissue type-cerebral cortex (precentral gyrus and supplementary motor area), subcortical regions (thalamus and putamen), and cerebellar cortex (superior lobule). The observed changes in R2* from activation-induced oxygenation changes were more variable across brain regions with different tissue characteristics than observed changes in R2. The ratio of deltaR2* to deltaR2 was 3.3 +/- 0.9 for cerebral cortex and 2.0 +/- 0.6 for subcortical tissue. deltaR2*, deltaR2, and relative blood flow changes were deltaR2* = -0.201 +/- 0.040 (s-1), deltaR2 = -0.064 +/- 0.011 s(-1), and deltaf/f = 16.7 +/- 0.8% in the cerebral cortex; deltaR2* = -0.100 +/- 0.026 s(-1), deltaR2 = -0.049 +/- 0.009 s(-1), and deltaf/f = 9.4 +/- 0.7% in the subcortical regions; and deltaR2* = -0.215 +/- 0.093 s(-1), deltaR2 = -0.069 +/- 0.012 s(-1), and deltaf/f = 16.2 +/- 1.2% in the cerebellar cortex.
机译：在1.5特斯拉（T）处进行自旋回波和梯度回波回波平面功能磁共振成像（fMRI）研究，以获取7名强右手女性在执行过程中全脑的血氧水平依赖性（BOLD）对比图像。复杂的运动任务。五名受试者在执行相同任务的同时进行了后续的H215O正电子发射断层扫描（PET）研究。据报道，在九个皮质，皮质下和小脑运动区，神经元激活后，在1.5T时MRI弛豫率R2 *和R2的变化的团体平均结果。每种方法的结果均根据组织类型-脑皮质（中央回和运动辅助区），皮质下区域（丘脑和壳核）和小脑皮质（上小叶）进行分组。与观察到的R2变化相比，在具有不同组织特征的大脑区域中，由激活诱导的氧合变化引起的R2 *变化观察到的变化更大。对于大脑皮层，deltaR2 *与deltaR2的比率为3.3 +/- 0.9，而对于皮层下组织为2.0 +/- 0.6。 deltaR2 *，deltaR2和相对血流变化分别为deltaR2 * = -0.201 +/- 0.040（s-1），deltaR2 = -0.064 +/- 0.011 s（-1）和deltaf / f = 16.7 +/- 0.8大脑皮层中的百分比;在皮层下区域中deltaR2 * = -0.100 +/- 0.026 s（-1），deltaR2 = -0.049 +/- 0.009 s（-1），并且deltaf / f = 9.4 +/- 0.7％;小脑皮质中的deltaR2 * = -0.215 +/- 0.093 s（-1），deltaR2 = -0.069 +/- 0.012 s（-1）和delf / f = 16.2 +/- 1.2％。

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