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首页> 外文期刊>Journal of Chemical Technology & Biotechnology >Extraction of erythromycin-A using colloidalliquid aphrons:I.Equilibrium partitioning
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Extraction of erythromycin-A using colloidalliquid aphrons:I.Equilibrium partitioning

机译：胶体液泡芙提取红霉素A的研究：I。平衡分配

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摘要

Colloidal liquid aphrons (CLAs) are surfactant-stabilised solvent droplets which have recently been explored for use in pre-dispersed solvent extraction (PDSE). In this work, the equi-librium partitioning of a microbial secondary metabolite, erythromycin, has been studied using both CLAs (formulated from 10/0 (wlv) Softanol 120 in decanol and 0.5% (wlv) SDS in water) and surfactant-containing, two-phase systems. The equilibrium partitioning of erythromycin was found to be strongly influenced by the extraction pH, and exhibited a marked change either side of the pK~ of the molecule. A modified form of the Henderson—Hasselbach equation could be used as a simple design equation to predict the equilibrium partition coefficient ~ = Corg ICaq) as a function of pH. For extraction e~xperiments with dispersed CLAs where PH> pKa, me,~yt values as high as 150 could be obtained and the erythromycin could be concentrated by factors of up to 100. Experiments were also carried out in surfactant-containing, two-phase systems to determine the effect of individual surfactants used for aphron formulation on erythromycin partitioning. For extraction at pH 10 neither the Softanol (a non-ionic surfactant) nor SDS (an anionic surfactant) had any influence on the equilibrium erythromycin partition coefficients. For stripping at pH 7, however, it was found that recovery of erythromycin from the organic phase decreased with increasing concentration of SDS, although again the Softanol had no influence on the equilibrium. The effect of SDS was attributed to a specific electrostatic interaction between individual erythromycin and SDS molecules under stripping conditions. The values and concentration factors achievable in the two-phase systems were considerably less than those for the PDSE experiments. The physical properties of the two-phase systems, ie density, viscosity, interfacial tension, etc, and the equilibrium distribution of the surfactants were also determined in relation to subsequent studies on the kinetics of erythromycin extraction.
机译：胶体液体氩气（CLA）是表面活性剂稳定的溶剂滴，最近已被研究用于预分散溶剂萃取（PDSE）。在这项工作中，已经使用CLA（由癸醇中的10/0（wlv）Softanol 120和水中的0.5％（wlv）SDS配制）和含表面活性剂的微生物次生代谢物红霉素的平衡库分配进行了研究。 ，两相系统。发现红霉素的平衡分配受到提取pH的强烈影响，并且在分子pK〜的任一侧均表现出显着变化。可以将Henderson-Hasselbach方程的修改形式用作简单的设计方程，以预测作为pH函数的平衡分配系数（= Corg ICaq）。对于PH> pKa的分散CLA萃取物，可以得到高达150的me，yt值，并且可以将红霉素的浓缩倍数提高至100。相系统来确定用于Aphron制剂的各个表面活性剂对红霉素分配的影响。对于在pH 10的萃取，Softanol（一种非离子表面活性剂）和SDS（一种阴离子表面活性剂）都对平衡红霉素分配系数没有任何影响。然而，对于在pH 7的汽提，发现随着SDS浓度的增加，从有机相中回收的红霉素会降低，尽管同样，Softanol对平衡也没有影响。 SDS的作用归因于溶出条件下单个红霉素和SDS分子之间的特定静电相互作用。在两相系统中可达到的值和浓度因子远小于PDSE实验中的值和浓度因子。还与随后对红霉素提取动力学的研究有关，确定了两相体系的物理性质，即密度，粘度，界面张力等，以及表面活性剂的平衡分布。

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