The title compound, 3-{2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-napthalenyl]ethylidene}dihydro-4-acetoxy-2(3H)-furanone, C22H32O6, was synthesised from andrographolide. It crystallizes in the orthorhombic system with a = 7.4219(12), b = 11.8411(10), c = 23.777(4) angstrom in space group P2(1)2(1)2(1). While the stereochemical relation between rings is slightly changed from the starting material, acetylation of the hydroxyfuranone moiety completely abolishes O-H center dot center dot center dot O hydrogen bonding there, leaving a C-H center dot center dot center dot O interaction. The hydrogen-bonded chains at the opposite end of the andrographolide molecule persist but reverse direction.
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机译：标题化合物3- {2- [十氢-6-羟基-5-（羟甲基）-5,8a-二甲基-2-亚甲基-1-萘基]亚乙基}二氢-4-乙酰氧基-2（3H）-呋喃酮由穿心莲内酯合成C 22 H 32 O 6。它在正交晶系中以a = 7.4219（12），b = 11.8411（10），c = 23.777（4）埃在空间群P2（1）2（1）2（1）中结晶。当环之间的立体化学关系从起始原料稍微改变时，羟基呋喃酮部分的乙酰化完全消除了在那里的O-H中心点中心点中心点O氢键，留下了C-H中心点中心点中心点O相互作用。穿心莲内酯分子另一端的氢键链保持不变，但方向相反。
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