The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.

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The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

机译：S-甲基二硫代咔唑与靛红衍生的中心对称铜（II）配合物的晶体结构和细胞毒性

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Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC _(50) value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) _2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur.

机译：制备了S-甲基二硫代氨基甲酸铜与靛红的铜（II）配合物，并筛选了它们对MCF-7（人类非转移性乳腺腺癌细胞）和MDA-MB-231（人类转移性乳腺腺癌细胞）的细胞毒活性。。该化合物在正交晶体系统中以C 2cb空间群结晶，发现对MCF-7细胞系具有选择性活性（人非转移性乳腺腺癌细胞系，IC _（50）值为0.45μg/ mL。该中心对称的Cu（SMISA）_2配合物的结构（SMISA =通过S-甲基二硫代氨基甲酸酯与靛红的缩合反应形成的席夫碱），表明铜原子具有扭曲的方平面几何形状，席夫碱与金属离子协调一致通过偶氮甲氮和硫醇硫带入二齿配体。

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《Journal of chemical crystallography》 |2011年第12期|共6页
作者
Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.;
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正文语种 eng
中图分类晶体学;
关键词
Centrosymmetric; Copper(II); Dithiocarbazate; MCF-7; Schiff base;

机译：中心对称;铜（II）;二硫代氨基甲酸酯;MCF-7;席夫碱;

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1. The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin [J] . Manan M.A.F.A., Tahir M.I.M., Crouse K.A., Journal of chemical crystallography . 2011,第12期

机译：S-甲基二硫代咔唑与靛红衍生的中心对称铜（II）配合物的晶体结构和细胞毒性
2. Preparation, spectroscopic characterization and X-ray crystal and molecular structures of nickel(II), copper(II) and zinc(II) complexes of the Schiff base formed from isatin and S-methyldithiocarbazate (Hisa-sme) [J] . Ali MA, Abu Bakar HJH, Mirza AH, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2008,第1期

机译：靛红和S-甲基二硫代咔唑形成的席夫碱的镍（II），铜（II）和锌（II）配合物的制备，光谱表征，X射线晶体和分子结构
3. Antitumor Activity of Manganese(II) and Cobalt(III) Complexes of 2-Acetylpyridine Schiff Bases Derived from S-Methyldithiocarbazate: Synthesis, Characterization, and Crystal Structure of the Manganese(II) Complex of 2-Acetylpyridine S-Methyldithiocarbazate [J] . C. L. Chen, X. F. Zhu, M. X. Li Russian Journal of Coordination Chemistry . 2011,第6期

机译：S-甲基二硫代咔唑的2-乙酰基吡啶席夫碱锰（II）和钴（III）配合物的抗肿瘤活性：2-乙酰基吡啶S-甲基二硫代咔唑的锰（II）配合物的合成，表征和晶体结构
4. Synthesis and crystal structure of copper( II) complex derived from N-(4,6-dimethylpyrimidin)-N'-(ethoxycarbonyl)thiourea [C] . Yinghui Ren, Haixia Ma, Kangzhen Xu International Conference on Chemical, Material and Metallurgical Engineering . 2012

机译：衍生自N-（4,6-二甲基嘧啶）-N' - （乙氧基羰基）硫脲的铜（II）络合物的合成和晶体结构
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机译：I.某些咪唑基桥接铜（II）配合物的合成，溶液行为，晶体结构和磁性。二。含碳桥基的三铜（II）簇的晶体结构和磁性。
6. Less toxic zinc(ii) diorganotin(iv) gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine NN-dimethylthiosemicarbazone: synthesis crystal structures cytotoxicity and investigations of mechanisms of action [O] . Yan Fang, Jie Li, Pei-Pei Han, 2018

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机译：S-MethythiThiocarbazate（SMDTC）的二齿NS异构席基碱的Cu（II），Ni（II），Ni（II），Ni（II）和Zn（II）金属络合物的合成及表征：二齿NS异构席夫群的生物活性，其中一些Cu（II）），Ni（II）和Zn（II）复合物和双BIS的X射线结构S-甲基-β-N-（2-呋喃基 - 甲基）甲基二硫代氨基甲苯锌（II）复合物
8. CRYSTAL STRUCTURES OF NICKEL AND COPPER COMPOUNDS PART I. TWO BIS COMPLEXES OF 2.2’-IMINOBIS (ACETAMIDOXIME) PART II REGULAR OCTAHEDRAL COPPER (II) COMPLEXES [R] . DAVID LAWRENCE CULLEN 1969

机译：镍和铜化合物的晶体结构第一部分2.2'-亚氨基（乙酰氨基）第二部分正二甲基铜（Ⅱ）配合物的两个双配合物

The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

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