Challenges of combining cytotoxic chemotherapy and tyrosine kinase inhibitors

Michael P Chu; Vijaya L Damaraju; Michael B Sawyer

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Challenges of combining cytotoxic chemotherapy and tyrosine kinase inhibitors

机译：细胞毒性化疗和酪氨酸激酶抑制剂联合使用的挑战

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Single-agent tyrosine kinase inhibitors (TKIs) have significantly improved patient outcomes across multiple tumor subtypes. However, TKI therapy is rarely curative. Early optimism of combining TKIs with cytotoxic chemotherapy failed to produce substantial results in numerous randomized studies. This article highlights potential missteps and improvements in combination therapy thus far, while shedding light on potential improvements for future combinations.

机译：单药酪氨酸激酶抑制剂（TKI）在多种肿瘤亚型中均显着改善了患者预后。但是，TKI治疗很少能治愈。在许多随机研究中，将TKI与细胞毒性化学疗法联合使用的早期乐观未能产生实质性结果。本文重点介绍了迄今为止在联合治疗中可能出现的失误和改进，同时阐明了未来联合治疗的潜在改进。

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《Clinical investigation》 |2015年第1期|共8页
作者
Michael P Chu; Vijaya L Damaraju; Michael B Sawyer;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
gemcitabine; nucleoside transporters; tyrosine kinase inhibitors;

机译：吉西他滨;核苷转运蛋白;酪氨酸激酶抑制剂;

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1. 表皮生长因子受体酪氨酸激酶抑制剂联合化疗治疗晚期肺腺癌的疗效及安全性分析 [J] . 马晓, 张帅, 崔斌, 癌症（英文版） . 2019,第011期
2. Challenges of combining cytotoxic chemotherapy and tyrosine kinase inhibitors [J] . Michael P Chu, Vijaya L Damaraju, Michael B Sawyer Clinical investigation . 2015,第1期

机译：细胞毒性化疗和酪氨酸激酶抑制剂联合使用的挑战
3. FIRST-LINE TREATMENT WITH EPIDERMAL GROWTH FACTOR RECEPTOR-TYROSINE KINASE INHIBITOR (EGFR-TKI) VERSUS CYTOTOXIC CHEMOTHERAPY IN PATIENTS WITH SENSITISING EGFR MUTATION-POSITIVE ADVANCED LUNG ADENOCARCINOMA [J] . Chai Chee Shee, Liam Chong-Kin, Pang Yong-Kek, Respirology : . 2015,第Suppla3期

机译：表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）与细胞毒化学疗法对敏感的EGFR突变阳性的高级肺腺癌的一线治疗
4. Cytotoxic chemotherapy may overcome the development of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) therapy [J] . Kanda Shintaro, Horinouchi Hidehito, Fujiwara Yutaka, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2015,第3期

机译：细胞毒性化学疗法可以克服对表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKIs）治疗的获得性耐药性的发展
5. USING TYROSINE KINASE INHIBITORS AND METRONOMIC CHEMOTHERAPY TO IMPROVE ANTITUMORIMMUNITY IN DOGS [C] . Barb Biller Conference of the American College of Veterinary Internal Medicine . 2014

机译：使用酪氨酸激酶抑制剂和衡量化疗，从而改善狗的抗肿瘤
6. Analysis of pp60c-src and pp62c-yes intracellular protein tyrosine kinase function in colon tumor cell growth regulation using herbimycin A, a tyrosine kinase specific inhibitor. [D] . Garcia, Roy. 1995

机译：使用酪氨酸激酶特异性抑制剂除草霉素A分析pp60c-src和pp62c-yes细胞内蛋白酪氨酸激酶在结肠肿瘤细胞生长调节中的功能。
7. The Risk of Herpes Zoster in Patients with Non-small Cell Lung Cancer according to Chemotherapy Regimens: Tyrosine Kinase Inhibitors versus Cytotoxic Chemotherapy [O] . Ji Young Choi, Miso Kim, Bhumsuk Keam, 2019

机译：根据化疗方案非小细胞肺癌患者带状疱疹的风险：酪氨酸激酶抑制剂与细胞毒性化疗
8. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin [O] . Hideki Tanaka, Hirotsugu Hino, Shota Moriya, 2020

机译：通过癌细胞抑制与阿奇霉素组合治疗中癌细胞自噬的癌细胞自噬和增强细胞毒性的自噬诱导性比较
9. EgF Receptor Mabs and Chemotherapy/Characterization of Synergistic Interactions Between Cytotoxic Agents and Inhibitors of the Tyrosine Kinase Growth Factor Receptor Signalling Cascade [R] . Seidman, A. D. 1998

机译：EgF受体单克隆抗体和化疗/表征细胞毒性剂和酪氨酸激酶生长因子受体信号级联抑制剂之间协同作用的相互作用

Challenges of combining cytotoxic chemotherapy and tyrosine kinase inhibitors

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