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Cancer therapy with Newcastle disease virus: rationale for new immunotherapeutic combinations

机译：新城疫病毒的癌症治疗：新的免疫治疗组合的原理

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Cancer immunotherapy with Newcastle disease virus (NDV) dates back to 1960s, when intratumoral treatment of a cervical cancer patient was noted to result in an abscopal effect with distant tumor regression. Since then, multiple preclinical and clinical studies have demonstrated the inherent ability of NDV to increase immunogenicity of tumor cells. Recently, these properties were explored in animal models within the context of novel immunotherapies such as antibodies targeting immune checkpoints, with demonstration of induction of systemic antitumor immunity and regression of tumors not directly affected by the virus. These studies highlight the immunotherapeutic potential of NDV and provide a strong rationale for exploration of NDV and perhaps other oncolytic viruses in combination with immunomodulatory antibodies in the clinic.
机译：用新城疫病毒（NDV）进行的癌症免疫疗法可以追溯到1960年代，当时人们发现对子宫颈癌患者进行肿瘤内治疗会产生明显的疗效，并导致远处的肿瘤消退。从那时起，多项临床前和临床研究证明了NDV增加肿瘤细胞免疫原性的内在能力。最近，在新型免疫疗法（例如针对免疫检查点的抗体）的动物模型中探索了这些特性，并证明了诱导的全身性抗肿瘤免疫力和不受病毒直接影响的肿瘤消退。这些研究突出了NDV的免疫治疗潜力，并为在临床中探索NDV和其他溶瘤病毒与免疫调节抗体的结合提供了强有力的依据。

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