Identification of a novel class of orally active pyrimido(5,4-3)(1,2,4)triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

Guertin KR; Setti L; Qi L; Dunsdon RM; Dymock BW; Jones PS; Overton H; Taylor M; Williams G; Sergi JA; Wang K; Peng Y; Renzetti M; Boyce R; Falcioni F; Garippa R; Olivier AR

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Identification of a novel class of orally active pyrimido(5,4-3)(1,2,4)triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

【24h】

Identification of a novel class of orally active pyrimido(5,4-3)(1,2,4)triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

机译：具有蛋白质酪氨酸磷酸酶抑制活性的新型口服活性嘧啶（5,4-3）（1,2,4）三嗪-5,7-二胺类降血糖药的鉴定。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.

机译：已经确定了一系列新颖的口服活性嘧啶并[5,4-3] [1,2,4]三嗪-5,7-二胺基降血糖药。这些化合物对包括PTP1B在内的一组蛋白质酪氨酸磷酸酶显示出非选择性的抑制特性。化合物12和13在ob / ob小鼠中显示口服葡萄糖降低作用。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第17期|共4页
作者
Guertin KR; Setti L; Qi L; Dunsdon RM; Dymock BW; Jones PS; Overton H; Taylor M; Williams G; Sergi JA; Wang K; Peng Y; Renzetti M; Boyce R; Falcioni F; Garippa R; Olivier AR;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
novel; Protein-Tyrosine-Phosphatase; Triazines; Hypoglycemic Agents; 蛋白质酪氨酸磷酸酶; 三嗪类; 降血糖药;

机译：novel;Protein-Tyrosine-Phosphatase;Triazines;Hypoglycemic Agents;蛋白质酪氨酸磷酸酶;三嗪类;降血糖药;

相似文献

外文文献
中文文献
专利

1. Identification of a novel class of orally active pyrimido(5,4-3)(1,2,4)triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity. [J] . Guertin KR, Setti L, Qi L, Bioorganic and Medicinal Chemistry Letters . 2003,第17期

机译：具有蛋白质酪氨酸磷酸酶抑制活性的新型口服活性嘧啶（5,4-3）（1,2,4）三嗪-5,7-二胺类降血糖药的鉴定。
2. New prenylated flavanones from Erythrina abyssinica with Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. [J] . Cui L, Lee HS, Ndinteh DT, Planta medica: Natural products and medicinal plant research . 2010,第7期

机译：来自刺桐的新异戊烯黄酮具有蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性。
3. Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents [J] . Toshihisa Onoda, Wei Li, Koji Higai, BMC Complementary and Alternative Medicine . 2014,第1期

机译：评估147种Kampo处方作为新型蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂
4. Characterization of Novel Oxidation Products of Cysteine in Synthetic Active Site motif HCSAGIGRS of Protein Tyrosine Phosphatase 1B [C] . Vivekananda Shetty, Thomas A Neubert ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：蛋白质酪氨酸磷酸酶1B蛋白酪氨酸磷酸酶1B中半胱氨酸新型氧化产物的表征
5. Regulation of NMDAR function by tyrosine phosphorylation: The role of extracellular zinc and identification of the tyrosine phosphatase step as an endogenous regulator of NMDAR activity. [D] . Pelkey, Kenneth Allen. 2002

机译：酪氨酸磷酸化调节NMDAR功能：胞外锌的作用和酪氨酸磷酸酶步骤的鉴定是NMDAR活性的内源性调节剂。
6. Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents [O] . Toshihisa Onoda, Wei Li, Koji Higai, 2014

机译：评估147种Kampo处方作为新型蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂
7. Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents [O] . Toshihisa Onoda, Wei Li, Koji Higai, 2014

机译：评估147种Kampo处方作为新型蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂

Identification of a novel class of orally active pyrimido(5,4-3)(1,2,4)triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

摘要

著录项

相似文献

相关主题

期刊订阅