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首页> 外文期刊>Journal of chemical neuroanatomy >The hypothalamic ventral premammillary nucleus: A key site in leptin's regulation of reproduction
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The hypothalamic ventral premammillary nucleus: A key site in leptin's regulation of reproduction

机译:下丘脑腹侧前乳核:瘦素调节生殖的关键部位

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摘要

Reproduction is an energy-expensive process that relies on indicators of energy availability to adjust its proper functioning. The adipokine leptin provides one such metabolic signal, with leptin receptorexpressing neurons at sites widespread within the CNS, including regions associated with the neuroendocrine reproductive axis. One substantial population lies within the hypothalamic ventral premammillary nucleus (PMv), a region itself linked to reproductive control, which may provide a strategic site for the integration of energy availability, sensory and gonadal cues. Here we review our current understanding of leptin and PMv regulation of reproduction, including emerging details about intracellular mechanisms of leptin action at this site. (C) 2014 Elsevier B.V. All rights reserved.
机译:繁殖是一个耗费能源的过程,它依赖于能源可用性指标来调整其正常功能。脂肪因子瘦素提供一种这样的代谢信号,在中枢神经系统内广泛分布的部位(包括与神经内分泌生殖轴相关的区域)表达瘦素受体的神经元。下丘脑腹侧前乳核(PMv)本身是一个重要的种群,该区域本身与生殖控制有关,这可能为整合能量可用性,感觉和性腺暗示提供了战略要地。在这里,我们回顾我们目前对瘦素和PMv调控繁殖的理解,包括有关该部位瘦素作用的细胞内机制的新出现细节。 (C)2014 Elsevier B.V.保留所有权利。

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