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Yield of contact investigations in households of patients with drug-resistant tuberculosis: Systematic review and meta-analysis

机译：耐药结核病患者家庭接触调查的收益：系统评价和荟萃分析

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Contact investigations among individuals living with drug-susceptible tuberculosis patients (source cases) have shown a high yield of tuberculosis disease and latent tuberculosis, but the yield of such investigations in households of drug-resistant tuberculosis source cases is unknown. In this systematic review and meta-analysis, we found 25 studies that evaluated a median of 111 (interquartile range, 21-302) household contacts of drug-resistant tuberculosis source cases. The pooled yield was 7.8% (95% CI, 5.6%-10.0%) for active tuberculosis and 47.2% (95% CI, 30.0%-61.4%) for latent tuberculosis, although there was significant statistical heterogeneity (P <. 0001). More than 50% of secondary cases with drug susceptibility test results were concordant with those of the source case. Among studies that followed household members, the majority of secondary cases were detected within 1 year of the source case's diagnosis. Household contact investigation around drug-resistant tuberculosis patients is a high-yield intervention for detection of drug-resistant tuberculosis and prevention of ongoing transmission.
机译：对患有药物敏感性结核病患者的个人（源病例）进行的接触调查显示，结核病和潜伏性结核病的收成很高，但是在耐药结核源病例的家庭中这种调查的结果尚不清楚。在这项系统的回顾和荟萃分析中，我们发现了25项研究，评估了耐药结核病源病例的家庭接触的中位数为111（四分位间距为21-302）。尽管有显着的统计异质性，活动性结核病的合并产率为7.8％（95％CI，5.6％-10.0％），潜伏性结核病的合并产率为47.2％（95％CI，30.0％-61.4％） 。超过50％的具有药敏测试结果的继发病例与源病例一致。在家庭成员的研究中，大多数继发病例是在诊断出源病例后的一年内发现的。对耐药结核病患者进行家庭接触调查是一项高产干预措施，可用于检测耐药结核病并预防持续传播。

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