A novel and efficient synthesis of anti-cancer agent, mereletinib

Liu Haidong; Lv Yongfeng; Li Yuan; Cai Jin; Chen Junqing; Qin Yu; Ji Min

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A novel and efficient synthesis of anti-cancer agent, mereletinib

机译：一种新型，高效的抗癌药mereletinib的合成

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A convenient route for the synthesis of a third-generation epidermal growth factor receptor inhibitor, mereletinib (AZD9291) using starting materials that are commercially available has been achieved through reactions that are readily conducted under mild conditions. Importantly, a 5 g scale synthesis was also accomplished and this method could therefore be useful in the synthesis of similar drugs.

机译：通过在温和条件下容易进行的反应，已经获得了使用可商购的起始原料合成第三代表皮生长因子受体抑制剂mereletinib（AZD9291）的便捷途径。重要的是，还完成了5 g规模的合成，因此该方法可用于合成相似的药物。

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来源
《Journal of chemical research: reviews and research papers from all branches of chemistry》 |2015年第6期|共3页
作者
Liu Haidong; Lv Yongfeng; Li Yuan; Cai Jin; Chen Junqing; Qin Yu; Ji Min;
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正文语种 eng
中图分类化学;
关键词
irreversible inhibitor; non-small-cell lung cancer; AZD9291; epidermal growth factor receptor; mereletinib; 3-(pyrimidin-4-yl)indole;

机译：不可逆抑制剂;非小细胞肺癌;AZD9291;表皮生长因子受体;司马列替尼;3-（嘧啶-4-基）吲哚;

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1. A novel and efficient synthesis of anti-cancer agent, mereletinib [J] . Liu Haidong, Lv Yongfeng, Li Yuan, Journal of chemical research: reviews and research papers from all branches of chemistry . 2015,第6期

机译：一种新型，高效的抗癌药mereletinib的合成
2. An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents. [J] . Yan SJ, Liu YJ, Chen YL, Bioorganic and Medicinal Chemistry Letters . 2010,第17期

机译：杂环融合1,2,3-三唑衍生物的有效单盆合成作为抗癌剂。
3. An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents. [J] . Yan SJ, Liu YJ, Chen YL, Bioorganic and Medicinal Chemistry Letters . 2010,第17期

机译：杂环融合1,2,3-三唑衍生物的有效单盆合成作为抗癌剂。
4. Pharmaco-imaging Analysis of Anti-cancer Agents Tumor Tissues Using Mass Microscope [C] . Shuich SHIMMA, Yuki TAKASHIMA, Akinobu HAMADA American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：抗癌剂肿瘤组织的药物成像分析使用质量显微镜
5. Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents [D] . Doshi, Arpit. 2019

机译：基于嘧啶的杂环作为潜在抗癌剂的设计与合成，具有组合化疗潜力或靶向一种碳代谢抑制和抗机会性药物
6. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-123-triazoles as potential anti-cancer agents [O] . Narsimha Reddy Penthala, Leena Madhukuri, Shraddha Thakkar, -1

机译：新型杂环-（2H）-123-三唑类化合物的合成及抗癌作用筛选
7. Design and synthesis of new metallo-organic complexes and their evaluation as anti-cancer agents. Synthesis, characterisation and biological evaluation of novel, late first row transition metal schiff base complexes, as anti-cancer metallopharmaceuticals [O] . Lidster Jon 2011

机译：新的金属有机配合物的设计和合成及其作为抗癌药的评估。新型，第一排晚期过渡金属席夫碱复合物的合成，表征和生物学评价，作为抗癌金属药物

A novel and efficient synthesis of anti-cancer agent, mereletinib

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