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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >The relationship between brachial artery flow-mediated dilatation, high sensitivity C-reactive protein, and uterine artery doppler velocimetry in women with pre-eclampsia.
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The relationship between brachial artery flow-mediated dilatation, high sensitivity C-reactive protein, and uterine artery doppler velocimetry in women with pre-eclampsia.

机译：先兆子痫妇女的肱动脉血流介导的扩张，高敏C反应蛋白和子宫动脉多普勒测速仪之间的关系。

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PURPOSE: To investigate serum high sensitivity C-reactive protein (hs-CRP) levels and endothelial function in pregnancies complicated by pre-eclampsia and to clarify their relationship with uterine artery Doppler velocimetry. METHODS: A cross-sectional study was carried out in 70 pregnant women (35 patients with pre-eclampsia and 35 age-matched normotensive healthy pregnant women) during the third trimester of pregnancy. The maternal levels of serum hs-CRP were determined in all cases by immunonephelometry. Uterine artery Doppler velocimetry was performed. Flow-mediated dilatation was measured by sonography of the brachial artery for the assessment of endothelial function. RESULTS: Serum hs-CRP levels were higher in the pre-eclamptic group than in the normotensive group. hs-CRP levels were positively correlated with mean arterial pressure. Eleven patients with pre-eclampsia had abnormal uterine artery Doppler velocimetry. hs-CRP levels were significantly higher in pre-eclamptic patients with than without abnormal uterine artery Doppler velocimetry. Endothelial function was inversely correlated with hs-CRP levels and mean arterial pressure. CONCLUSIONS: These findings suggest that maternal serum hs-CRP levels increase with the severity of pre-eclampsia, reflecting endothelial dysfunction and constituting a potential marker of pathological utero-placental perfusion, with a high risk for fetal growth restriction.
机译：目的：探讨妊娠合并先兆子痫的孕妇血清高敏C反应蛋白（hs-CRP）水平和内皮功能，并阐明其与子宫动脉多普勒测速仪的关系。方法：在妊娠中期，对70名孕妇（35名先兆子痫患者和35名年龄匹配的血压正常健康孕妇）进行了横断面研究。在所有情况下，通过免疫比浊法测定孕妇的血清hs-CRP水平。进行子宫动脉多普勒测速。通过肱动脉超声检查血流介导的扩张，以评估内皮功能。结果：先兆子痫组的血清hs-CRP水平高于正常血压组。 hs-CRP水平与平均动脉压呈正相关。 11例先兆子痫患者子宫动脉多普勒测速仪异常。先兆子痫前期患者的hs-CRP水平显着高于未异常子宫动脉多普勒测速仪。内皮功能与hs-CRP水平和平均动脉压呈负相关。结论：这些发现表明，孕妇血清hs-CRP水平随先兆子痫的严重程度而升高，反映出内皮功能障碍，构成病理性胎盘-胎盘灌注的潜在标志，胎儿生长受限的风险较高。

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