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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Ultrastructural biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver.
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Ultrastructural biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver.

机译：超声与脉搏反转和微泡造影剂在兔肝脏中的超微结构生物学效应。

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摘要

PURPOSE: This prospective study was conducted to evaluate the biologic effects of microbubble destruction with pulse-inversion harmonic imaging on rabbit liver parenchyma. METHODS: The livers of 6 albino rabbits were examined sonographically by a single investigator. Three rabbits underwent contrast-enhanced sonography, with scanning starting 5 seconds after injection by using pulse-inversion harmonic imaging with a mechanical index of 1.2. Four time-triggered images were recorded at a rate of 1 frame every 2 seconds. For comparison, 3 control rabbits had pulse-inversion harmonic imaging with a mechanical index of 1.2 only, without contrast medium. Immediately after sonography, the animals were killed and uninterrupted, thin serial sections of the liver from both groups were analyzed by energy-filtered transmission electron microscopy. RESULTS: The hepatic parenchyma of rabbits exposed to contrast agents had ultrastructural damage: mitochondria with fragmented crests; interrupted rough endoplasmic reticulum; enlarged intercellular spaces; highly vacuolized cytoplasmic areas; dilated sinusoids, sometimes with an irregular and interrupted endothelial wall; fragmented hepatocyte microvilli in dilated spaces of Disse; fragmented or missing microvilli in bile canaliculi; vacuolated and lysosome-deprived hepatic cytoplasm around the bile canaliculi; markedly injured or fragmented endothelium in larger vessels; and damaged basal membrane. Control-group results indicated that exposure to ultrasound alone did not cause ultrastructural damage to hepatic cells. CONCLUSIONS: Simultaneous exposure to contrast administration and pulse-inversion harmonic imaging with a high mechanical index causes ultrastructural damage in the rabbit liver.
机译：目的：进行这项前瞻性研究，以评估脉冲反转谐波成像对微泡破坏对兔肝实质的生物学影响。方法：由一名研究人员对6只白化病兔的肝脏进行超声检查。三只兔子进行了造影剂超声检查，注射后5秒钟开始使用机械强度为1.2的脉冲反转谐波成像进行扫描。每2秒以1帧的速率记录四个时间触发的图像。为了比较，对3只对照兔进行了脉冲反转谐波成像，其机械指数仅为1.2，没有造影剂。超声检查后，立即杀死动物并使其不间断，通过能量过滤透射电子显微镜分析两组肝脏的薄系列切片。结果：暴露于造影剂的家兔的肝实质具有超微结构损伤：线粒体具有波峰破碎;粗面内质网中断;扩大的细胞间空间;高度空泡的细胞质区域;窦道扩张，有时内皮壁不规则且间断; Disse散乱的空间中碎裂的肝细胞微绒毛;胆小管碎裂或缺失的微绒毛;胆管周围空泡和溶酶体剥夺的肝细胞质;较大血管中的内皮明显受伤或破碎;和受损的基底膜。对照组的结果表明，单独暴露于超声并不会引起肝细胞超微结构损伤。结论：同时暴露于造影剂和具有高机械指数的脉冲反转谐波成像会引起兔肝脏超微结构损伤。

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