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首页> 外文期刊>Journal of clinical rheumatology >Assessment of fatigue in rheumatoid arthritis (by functional assessment of chronic illness therapy-fatigue score) and its relation to disease activity and Anemia
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Assessment of fatigue in rheumatoid arthritis (by functional assessment of chronic illness therapy-fatigue score) and its relation to disease activity and Anemia

机译：类风湿关节炎疲劳评估（通过慢性疾病治疗功能评分-疲劳评分）及其与疾病活动性和贫血的关系

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Background: Patients with rheumatoid arthritis (RA) mention fatigue as one of their most annoying problems. Measuring fatigue, understanding its contributory factors, and treating it as a feasible target lead to better patient outcome and improved quality of life. The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System is a collection of health-related quality-of-life questionnaires targeted to the management of chronic illness. Objective: The objective of this study was to evaluate fatigue using FACIT-Fatigue (FACIT-F) score and its relation to disease activity (using Disease Activity Score [DAS28] and Clinical Disease Activity Index [CDAI] score) and anemia in RA patients. Methods: A total of 100 RA patients were evaluated for fatigue using FACIT-F score, for disease activity using DAS28 and CDAI scores, for anemia using hemoglobin levels. Correlation studies were done using Pearson test. RESULTS: Functional Assessment of Chronic Illness Therapy-Fatigue showed positive association with DAS28 (P < 0.001; r = -0.80) and CDAI (P < 0.001; r = -0.83). Considering various components of DAS28 and CDAI, FACIT-F showed significant correlation with tender joint count (P < 0.001; r = -0.73), swollen joint count (P < 0.001; r = -0.76), patient global assessment (P < 0.001; r = -0.72), and evaluator global assessment (P < 0.001; r = -0.75). Erythrocyte sedimentation rate had no association with the fatigue (P = 0.217). No association was observed between fatigue and hemoglobin levels (P = 0.203). CONCLUSION: The fatigue experienced by the patients with RA is strongly associated with the severity of disease activity and is independent of anemia.
机译：背景：类风湿关节炎（RA）患者提到疲劳是他们最烦人的问题之一。测量疲劳，了解其成因并将其视为可行的目标可以改善患者的预后并改善生活质量。慢性病治疗功能评估（FACIT）测量系统是针对慢性病管理的健康相关生活质量调查表的集合。目的：本研究旨在评估RA患者贫血的FACIT-Fatigue（FACIT-F）评分及其与疾病活动性（使用疾病活动性评分[DAS28]和临床疾病活动性指数[CDAI]评分）的关系。方法：采用FACIT-F评分评估100名RA患者的疲劳程度，使用DAS28和CDAI评分评估疾病活动性，使用血红蛋白水平评估贫血程度。相关研究使用皮尔森检验进行。结果：慢性疾病-疲劳的功能评估显示与DAS28（P <0.001; r = -0.80）和CDAI（P <0.001; r = -0.83）呈正相关。考虑到DAS28和CDAI的各个组成部分，FACIT-F与嫩关节计数（P <0.001; r = -0.73），肿胀关节计数（P <0.001; r = -0.76），患者总体评估（P <0.001）显着相关。 ; r = -0.72），以及评估者总体评估（P <0.001; r ​​= -0.75）。红细胞沉降率与疲劳无关（P = 0.217）。在疲劳和血红蛋白水平之间未发现关联（P = 0.203）。结论：RA患者经历的疲劳与疾病活动的严重程度密切相关，并且与贫血无关。

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