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首页> 外文期刊>Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology >Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization
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Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization

机译：HTLV前病毒载量定量在诊断与HTLV-1相关的脊髓病中的应用需要国际标准化

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摘要

The geographic distribution of Human T-cell Lymphotropic Virus Type 1 (HTLV-1) infection makes one thing clear: except Japan, most of the estimated 20 million infected individuals are clustered within communities with limited health care access. Given that the majority of infected persons remain disease-free, one of the challenges of the clinical management of HTLV-1 -infected patients with myelopathic symptoms is to establish the definite diagnosis of HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Asymptomatic carriers may complain of a range of symptoms that cannot be excluded from an association with HTLV-1, such as dry eyes, urinary incontinence and constipation. Current HAM/TSP diagnostic procedures are based on criteria established by the World Health Organization (WHO), which consists of a list of neurological signs and symptoms in HTLV-1 seropositive subjects. In addition, imaging of the central nervous system is essential to exclude other neurological diseases with similar clinical features, whilst isolation of HTLV-1 proviral in the cerebrospinal fluid (CSF) is a positive finding, especially when the viral load in CSF lymphocytes is greater than in PBMCs.
机译：人类T细胞1型淋巴病毒（HTLV-1）感染的地理分布清楚地表明了一件事情：除日本外，估计有2000万感染者中的大多数人聚集在医疗服务有限的社区内。鉴于大多数感染者仍保持无病状态，因此对患有HTLV-1感染，有骨髓病症状的患者进行临床管理的挑战之一是对HTLV相关性脊髓病/热带痉挛性轻瘫（HAM / TSP）进行明确诊断。无症状携带者可能会抱怨无法与HTLV-1结合排除的一系列症状，例如眼干，尿失禁和便秘。当前的HAM / TSP诊断程序基于世界卫生组织（WHO）建立的标准，该标准包括HTLV-1血清阳性受试者的神经系统症状和体征列表。此外，中枢神经系统成像对于排除具有相似临床特征的其他神经系统疾病至关重要，而在脑脊液（CSF）中分离HTLV-1前病毒是一项积极的发现，尤其是当CSF淋巴细胞的病毒载量更大时比PBMC要多。

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