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首页> 外文期刊>Journal of Comparative Pathology >Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population
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Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

机译：具有主要储备细胞群的犬皮脂腺肿瘤的组织病理学发现和增殖活性

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摘要

Sebaceous gland tumours represent the third most common skin tumours in dogs, but diagnostic criteria for tumours with basal differentiation (i.e. sebaceous epithelioma) are poorly defined and there is lack of correlation with biological behaviour. The aim of this study was to identify the main histological criteria associated with malignancy in 30 canine sebaceous gland tumours with a predominant reserve cell population. For each case, tumour proliferative activity was assessed by determining mitotic index and the Ki67/MIB-1 index. Additional histological features included endophytic or exophytic growth, proportion of reserve/intermediate/mature cells, connection to the epidermis, nuclear characteristics, peripheral invasion, neoplastic emboli and necrosis. Mitotic and Ki67 indexes were variable, but correlated (R = 0.66; P0.001), and both were significantly higher in infiltrative tumours (P = 0.018 and P0.001, respectively). No significant difference in histological features was observed between tumours comprised of more or less than 90% reserve cells, nor among tumours showing proliferative activity in sebocytes. This study suggests that high proliferative activity and peripheral invasion should be considered the most significant parameters for the differentiation between benign and malignant sebaceous gland tumours.
机译：皮脂腺肿瘤是犬中第三大最常见的皮肤肿瘤，但是具有基础分化的肿瘤（即皮脂腺上皮瘤）的诊断标准定义不明确，并且与生物学行为缺乏相关性。这项研究的目的是确定与30犬皮脂腺肿瘤的主要组织学标准相关的主要皮脂腺细胞储备。对于每种情况，通过确定有丝分裂指数和Ki67 / MIB-1指数来评估肿瘤的增殖活性。其他组织学特征包括内生或外生生长，储备/中间/成熟细胞的比例，与表皮的连接，核特征，外周侵袭，赘生物性栓塞和坏死。有丝分裂和Ki67指数是可变的，但相关（R = 0.66; P <0.001），在浸润性肿瘤中两者均显着较高（分别为P = 0.018和P <0.001）。在由多于或少于90％的储备细胞组成的肿瘤之间，以及在皮脂细胞中显示出增殖活性的肿瘤之间，没有观察到组织学特征的显着差异。这项研究表明，高增殖活性和外周侵袭应被视为区分良性和恶性皮脂腺肿瘤的最重要参数。

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