...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Comparative Pathology >Upregulation of Alveolar Levels of Activin B, but not Activin A, in Lungs of West Highland White Terriers with Idiopathic Pulmonary Fibrosis and Diffuse Alveolar Damage
【24h】

Upregulation of Alveolar Levels of Activin B, but not Activin A, in Lungs of West Highland White Terriers with Idiopathic Pulmonary Fibrosis and Diffuse Alveolar Damage

机译：在患有特发性肺纤维化和弥漫性肺泡损害的西部高地白梗的肺中，肺泡中活化素B而不是活化素A的肺泡水平上调

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Activins, cytokines belonging to the transforming growth factor-beta superfamily, have an important role in inflammation and fibrosis. Activin A has been suggested to participate in the pathophysiology of human idiopathic pulmonary fibrosis (IPF), but studies on the role of activin B are sparse. Canine IPF (CIPF) is an incurable interstitial lung disease occurring particularly in West Highland white terriers (WHWTs). During the disease course there are acute exacerbations (AEs) and the condition has a poor prognosis. Microscopically, AEs of CIPF are characterized by diffuse alveolar damage, which is also a key feature of acute respiratory distress syndrome (ARDS). The aim of this study was to study expression of activin A and B in lung tissue of WHWTs with CIPF and WHWTs with CIPF and concurrent AE, and dogs of various breeds with ARDS and to compare these findings with those of healthy WHWTs. In addition, western blot analysis of activin B from bronchoalveolar lavage fluid (BALF) from WHWTs with CIPF and healthy WHWTs was conducted. Activin B, but not activin A, was strongly expressed in the altered alveolar epithelium in the lungs of WHWTs with CIPF as well as in the lungs of dogs with ARDS. Activin B was detected in the BALF of WHWTs with CIPF, most notably in samples from dogs with AE, but activin B was not detected in BALF from healthy WHWTs. These findings suggest that activin B may be part of the pathophysiology of CIPF and might act as a marker of alveolar epithelial damage. (C) 2014 Elsevier Ltd. All rights reserved.
机译：激活素，属于转化生长因子-β超家族的细胞因子，在炎症和纤维化中起重要作用。有人认为激活素A参与人类特发性肺纤维化（IPF）的病理生理，但有关激活素B作用的研究很少。犬IPF（CIPF）是一种无法治愈的间质性肺疾病，特别是在西部高地白梗（WHWT）中发生。在疾病过程中会出现急性加重（AE），并且该病预后较差。在显微镜下，CIPF的AE具有弥漫性肺泡损伤的特征，这也是急性呼吸窘迫综合征（ARDS）的关键特征。这项研究的目的是研究激活素A和B在带有CIPF的WHWTs和带有CIPF并发AE的WHWTs的肺组织中，以及患有ARDS的各种犬的表达，并将这些发现与健康WHWTs的发现进行比较。另外，用CIPF和健康的WHWT对来自WHWT的支气管肺泡灌洗液（BALF）中的激活素B进行了蛋白质印迹分析。活化素B，而不是活化素A，在CIPF的WHWTs肺部和ARDS犬的肺部肺泡上皮中表达强烈。在带有CIPF的WHWT的BALF中检测到了激活素B，最明显的是在有AE犬的样本中检测到了激活素B，但是在来自健康WHWT的BALF中未检测到激活素B。这些发现表明，激活素B可能是CIPF病理生理的一部分，并且可能是肺泡上皮损伤的标志物。 （C）2014 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号