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首页> 外文期刊>Journal of Comparative Pathology >Skeletal Pathology of Eastern Grey Kangaroos (Macropus giganteus) Exposed to High Environmental Fluoride Levels in South-Eastern Australia
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Skeletal Pathology of Eastern Grey Kangaroos (Macropus giganteus) Exposed to High Environmental Fluoride Levels in South-Eastern Australia

机译：在澳大利亚东南部暴露于高浓度氟化物的东部灰袋鼠（Macropus giganteus）的骨骼病理

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摘要

Significantly elevated bone fluoride concentrations have been reported in a population of eastern grey kangaroos (Macropus giganteus) resident near a fluoride-emitting aluminum smelter in southeastern Australia. This paper describes the skeletal and synovial joint lesions observed post mortem in the same sample of kangaroos (n = 76). The prevalence and severity of skeletal lesions, specifically the formation of multiple, large, smooth exostoses over the diaphysis of long bones (especially, but not exclusively, on the tibia, fibula and metatarsi), were positively associated with bone fluoride concentration. So too were lesions of degenerative joint disease, including periarticular osteophytosis, articular cartilage erosion/ulceration, synovial hyperplasia and joint capsular fibrosis. Joint lesions were most commonly seen in the knee, hock and metatarsophalangeal joints. This is the first study to describe in detail the full range of lesions induced by chronic fluorosis in a marsupial species. (C) 2015 Elsevier Ltd. All rights reserved.
机译：据报道，居住在澳大利亚东南部一个散发氟化物的铝冶炼厂附近的东部灰色袋鼠（Macropus giganteus）种群中的骨氟化物浓度显着升高。本文描述了在同一袋鼠样本（n = 76）中，验尸后发现的骨骼和滑膜关节病变。骨骼病变的患病率和严重程度，特别是长骨的骨干（尤其是但不仅限于胫骨，腓骨和and骨）上形成多个大而光滑的外生骨，与骨氟化物浓度呈正相关。退行性关节疾病的病变也是如此，包括关节周围骨赘，关节软骨糜烂/溃疡，滑膜增生和关节囊纤维化。关节病变最常见于膝盖，飞节和meta趾关节。这是第一项详细描述有袋物种中慢性氟中毒诱发的全部病变的研究。 （C）2015 Elsevier Ltd.保留所有权利。

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