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首页> 外文期刊>Journal of Comparative Pathology >Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes
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Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes

机译：混合生殖细胞性索间质肿瘤在13只犬睾丸中的免疫组织化学研究

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摘要

Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-alpha and anti-Mullerian hormone (AMH). Cytokeratins AE1/AE3 (CK) and desmin (DES) were expressed in 6/13 and 8/13 cases, respectively. Neoplastic GCs were labelled for placental alkaline phosphatase (PLAP) in 7/13 cases and for CD117 (KIT) in 8/13 cases, while 10 cases were stained uniformly by periodic acid Schiff (PAS). Immature canine SCs are known to express CK, DES, INH-alpha and AMH, while immature GCs are stained by PAS and express PLAP and KIT. This GC phenotype also distinguishes between classical and spermatocytic seminoma, with the latter being negative for these markers. The results of the present study show that both neoplastic SCs and GCs in MGSCTs have a de-differentiated phenotype. (C) 2014 Elsevier Ltd. All rights reserved.
机译：混合生殖细胞性索间质肿瘤（MGSCT）由生精小管组成，充满了混合的赘生性支持细胞（SCs）和生殖细胞（GC）。本研究的目的是描述13种犬睾丸MGSCT，并研究肿瘤GC和SC的组织化学特征和免疫表型。赘生性SC总是被广泛标记有波形蛋白（VIM），神经元特异性烯醇酶（NSE），抑制素（INH）-α和抗穆勒激素（AMH）。细胞角蛋白AE1 / AE3（CK）和结蛋白（DES）分别在6/13和8/13例中表达。肿瘤GC标记有胎盘碱性磷酸酶（PLAP）（7/13例）和CD117（KIT）标记（8/13例），而10例被高碘酸希夫（PAS）均匀染色。已知不成熟的犬类SC表达CK，DES，INH-α和AMH，而不成熟的GC则被PAS染色并表达PLAP和KIT。该GC表型还可以区分经典精原细胞瘤和精子精原细胞瘤，后者对这些标志物是阴性的。本研究的结果表明，MGSCT中的肿瘤SC和GC均具有去分化的表型。 （C）2014 Elsevier Ltd.保留所有权利。

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