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首页> 外文期刊>Journal of Comparative Pathology >Immunohistochemical Labelling of Cyclooxygenase-2 in Lung Lesions of Calves Infected with Mycoplasma bovis
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Immunohistochemical Labelling of Cyclooxygenase-2 in Lung Lesions of Calves Infected with Mycoplasma bovis

机译：牛支原体感染小牛肺病变中环氧合酶-2的免疫组织化学标记

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摘要

The pathogenesis and persistence of Mycoplasma bovis (Mb) infection of the respiratory tract is incompletely understood. Cyclooxygenase (COX)-2 is overexpressed during inflammatory responses by different cell types in the lung. This study evaluated COX-2 expression immunohistochemically in the inflammatory lesions of calves with naturally occurring and experimentally induced Mb pneumonia. Experimentally infected lungs showed catarrhal bronchointerstitial pneumonia and varying degrees of peribronchiolar mononuclear cell cuffing. Lesions in calves with spontaneously arising disease included exudative bronchopneumonia and extensive foci of coagulative necrosis surrounded by inflammatory cells. Mb antigen was located in epithelial and inflammatory cells in the airway lumina and surrounding areas of necrosis. COX-2 protein was detected in the lung of all infected calves and was localized to goblet cells, bronchial, bronchiolar and alveolar epithelial cells and macrophages. COX-2 protein was overexpressed during Mb infection and was always associated with areas of pneumonia and with the presence of Mb antigen. (C) 2014 Elsevier Ltd. All rights reserved.
机译：呼吸道的牛支原体（Mb）感染的发病机理和持续性尚未完全了解。在肺部不同细胞类型的炎症反应过程中，环氧合酶（COX）-2过表达。这项研究通过免疫组织化学方法评估了自然发生和实验诱发的Mb肺炎的犊牛发炎性病变中COX-2的表达。经实验感染的肺显示出卡他性支气管间质性肺炎和不同程度的支气管周围单核细胞袖带。具有自发性疾病的犊牛的病变包括渗出性支气管肺炎和广泛的凝固性坏死灶，周围有炎性细胞。 Mb抗原位于气管腔和坏死周围区域的上皮细胞和炎性细胞中。在所有感染小牛的肺部均检测到COX-2蛋白，并定位于杯状细胞，支气管，支气管和肺泡上皮细胞以及巨噬细胞中。 COX-2蛋白在Mb感染过程中过表达，并且始终与肺炎区域和Mb抗原的存在有关。 （C）2014 Elsevier Ltd.保留所有权利。

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