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首页> 外文期刊>Journal of Comparative Pathology >Pathology of a Bohle-like Virus Infection in Two Australian Frog Species (Litoria splendida and Litoria caerulea)
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Pathology of a Bohle-like Virus Infection in Two Australian Frog Species (Litoria splendida and Litoria caerulea)

机译：两个澳大利亚蛙种（Litoria splendida和Litoria caerulea）的Bohle样病毒感染的病理学

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摘要

Gross and histopathological examination was performed on seven captive magnificent tree frogs (Litoria splendida) and one green tree frog (Litoria caerulea) that had died or been humanely destroyed while naturally infected with Mahaffey Road virus, a Bohle iridovirus-like ranavirus. Necropsy examination revealed skin lesions consisting of multiple small pale or haemorrhagic papules and ulcers in most frogs. Other common gross findings were perineural haemorrhage affecting the spinal nerves, hydrocoelom, hepatomegaly and splenomegaly with pinpoint pale foci throughout the parenchyma. On histological examination, vasculitis with prominent endothelial necrosis was found in a wide range of tissues. Widespread lymphoid necrosis and fibroblast necrosis were usual findings. Multifocal epithelial cell necrosis in the epidermis, liver and pancreas was found commonly. Non-suppurative meningoencephalitis, myelitis and ganglioneuritis were present variably. Intracytoplasmic basophilic inclusion bodies were found variably in hepatocytes, renal tubular epithelium and keratinocytes. Immunohistochemistry demonstrated ranavirus antigen in endothelial cells, fibroblasts, macrophages, lymphocytes and epithelial cells in a wide range of tissues. The finding of widespread venous and lymphatic endothelial necrosis and demonstration of abundant endothelial antigen suggests that endothelial tropism of the virus plays a significant role in the pathogenesis of the infection. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
机译：对七只被俘虏的宏伟的树蛙（Litoria splendida）和一只绿树蛙（Litoria caerulea）进行了肉眼和组织病理学检查，它们在自然感染了马菲路病毒（一种类似于Bohle虹膜病毒的鼻病毒）后死亡或被人道破坏。尸检表明，大多数青蛙的皮肤病变由多个小的苍白或出血性丘疹和溃疡组成。其他常见的总体发现是会累及脊髓实质的神经周围出血，鞘膜积液，肝肿大和脾肿大，并伴有淡淡的病灶。在组织学检查中，在广泛的组织中发现具有突出的内皮坏死的血管炎。普遍发现淋巴样坏死和成纤维细胞坏死。通常在表皮，肝脏和胰腺中发现多灶上皮细胞坏死。非化脓性脑膜脑炎，脊髓炎和神经节神经炎的表现各不相同。在肝细胞，肾小管上皮细胞和角质形成细胞中发现胞浆内嗜碱性包涵体存在差异。免疫组织化学表明，在广泛的组织中，内皮细胞，成纤维细胞，巨噬细胞，淋巴细胞和上皮细胞中存在着鼻病毒的抗原。广泛的静脉和淋巴管内皮坏死的发现以及丰富的内皮抗原的显示表明，病毒的内皮嗜性在感染的发病机理中起着重要作用。 Crown版权所有（C）2014，由Elsevier Ltd.发行。保留所有权利。

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