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首页> 外文期刊>Journal of Comparative Pathology >Histopathological Characterization of Cutaneous Delayed-type Hypersensitivity and Correlations with Intestinal Pathology and Systemic Immune Responses in Sheep with Paratuberculosis
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Histopathological Characterization of Cutaneous Delayed-type Hypersensitivity and Correlations with Intestinal Pathology and Systemic Immune Responses in Sheep with Paratuberculosis

机译：副结核病绵羊皮肤迟发型超敏反应的组织病理学特征及其与肠道病理和全身免疫反应的关系

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摘要

Cell-mediated immunity has been exploited historically in the diagnosis of mycobacterial diseases through elicitation of a delayed-type hypersensitivity (DTH) reaction following intradermal injection of an antigen. Here we describe the histopathological features of the cutaneous DTH reaction and its association with intestinal pathology and systemic immune responses in sheep with Mycobacterium avium subspecies paratuberculosis (MAP) infection. A mixed mononuclear cellular infiltrate dominated the DTH reaction and was present in perivascular and periadnexal patterns. Multiple multinucleate giant cells were present in the cellular infiltrate in one sheep while plasma cells were an obvious feature in six others. Sheep with paucibacillary intestinal lesions had the greatest degrees of cutaneous induration, more severe cellular infiltration in DTH lesions and high systemic interferon (IFN)-gamma production. In contrast, sheep with multibacillary intestinal lesions, and particularly those with dissemination of MAP to extra-intestinal tissues, had minimal cutaneous induration, nil to mild cellular infiltration in DTH lesions and high serum anti-MAP antibody levels. Systemic IFN-gamma production generally was augmented following skin sensitization. In general, the gross and histopathological features of the cutaneous DTH response matched the stage of paratuberculosis reflected by intestinal pathology and systemic measures of humoral and cellular immunity. (C) 2015 Elsevier Ltd. All rights reserved.
机译：历史上已经通过在皮内注射抗原后引发迟发型超敏反应（DTH）反应来诊断分枝杆菌疾病，并利用了细胞介导的免疫。在这里，我们描述了皮肤DTH反应的组织病理学特征，以及与绵羊分枝杆菌亚种副结核病（MAP）感染的绵羊肠道病理和全身免疫反应的关系。混合的单核细胞浸润占主导地位的DTH反应，并以血管周围和周围的形式存在。一只绵羊的细胞浸润液中存在多个多核巨细胞，而其他六只绵羊的浆细胞则具有明显的特征。带有丘脑小肠病变的绵羊皮肤硬结程度最高，DTH病变中的细胞浸润更为严重，全身性干扰素（IFN）-γ产生较高。相反，具有多细菌肠病变的绵羊，特别是那些将MAP扩散至肠外组织的绵羊，皮肤硬结最少，DTH病变中细胞浸润为零至轻度，而血清抗MAP抗体水平较高。皮肤致敏后，全身性IFN-γ产生通常会增加。通常，皮肤DTH反应的总体和组织病理学特征与肠道病理以及体液和细胞免疫的全身性措施所反映的结核病副阶段相匹配。 （C）2015 Elsevier Ltd.保留所有权利。

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