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首页> 外文期刊>Journal of Comparative Pathology >Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease
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Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease

机译：囊性卵巢疾病母牛卵巢卵泡中促炎性细胞因子的表达改变

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摘要

A growing body of evidence suggests that ovulation shares many of the features of an inflammatory reaction and that cytokines play many diverse and important roles in reproductive biology. The aim of this study was to examine the expression of the pro-inflammatory cytokines interleukin (IL)-1 alpha, IL-6 and tumour necrosis factor (TNF)-alpha in ovarian cells from cows with cystic ovarian disease (COD) as compared with that in ovarian structures from regularly cycling cows. Expression of genes encoding IL-1 alpha, IL-6 and TNF-alpha. was detected by real-time polymerase chain reaction in follicular cells from ovaries from healthy cows and cows with COD with no significant differences. However, immunohistochemistry showed increased expression of IL-1 alpha, IL-6 and TNF-alpha in cystic follicles, suggesting that this expression may be related to the persistence of follicular cysts. The effect of COD was evident for IL-1 alpha and TNF-alpha, and a follicular structure-disease interaction was observed in the expression of all the cytokines evaluated. Thus, altered expression of these proinflammatory cytokines may be related to ovulation failure and development of follicular cysts. (C) 2015 Elsevier Ltd. All rights reserved.
机译：越来越多的证据表明，排卵具有炎症反应的许多特征，而细胞因子在生殖生物学中起着多种多样且重要的作用。这项研究的目的是检查相比于患有囊性卵巢疾病（COD）的母牛卵巢细胞中促炎细胞因子白介素（IL）-1 alpha，IL-6和肿瘤坏死因子（TNF）-α的表达与定期骑牛的卵巢结构有关。编码IL-1α，IL-6和TNF-α的基因的表达。通过实时聚合酶链反应检测健康母牛和COD母牛卵巢卵泡细胞中的表达，无显着差异。然而，免疫组织化学显示，在囊性卵泡中IL-1α，IL-6和TNF-α的表达增加，提示该表达可能与卵泡囊肿的持续存在有关。 COD的作用对于IL-1α和TNFα很明显，并且在评估的所有细胞因子的表达中均观察到卵泡结构-疾病相互作用。因此，这些促炎细胞因子的表达改变可能与排卵失败和卵泡囊肿的发展有关。 （C）2015 Elsevier Ltd.保留所有权利。

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