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首页> 外文期刊>Clinical Biochemistry >Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes.
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Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes.

机译：妊娠或1型糖尿病孕妇的氧化和抗氧化状态。

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Objectives: To evaluate oxidative and antioxidative status in pregnant diabetic women between 26 and 32 weeks of gestation. Design and Methods: Free and total malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and vitamins A and E were determined in plasma and erythrocytes of 54 pregnant women. Among these, 27 were diabetics with either gestational diabetes mellitus (GDM), sub-group I, or previous insulin-dependent diabetes mellitus (type 1 diabetes), sub-group II. The other 27 patients were controls. Fasting plasma glucose and HbA(1c) levels were determined in all women. Results: HbA(1c) levels, plasma-, and erythrocyte-free MDA levels were significantly higher in all diabetic women and in both sub-groups than in controls. Plasma vitamin E and erythrocyte vitamin A levels were significantly lower in all diabetic women than in controls. Moreover, GPX and SOD activities were significantly reduced in all diabetic women, GPX in both sub-groups and SOD only in type 1 diabetes.Conclusions: The increased oxidative stress we demonstrated in pregnant women with previous type 1 diabetes or with GDM should be monitored by strictly controlling blood glucose during pregnancy with stringent recommendations and perhaps antioxidant supplementation.
机译：目的：评估妊娠26至32周之间的糖尿病孕妇的氧化和抗氧化状态。设计与方法：对54名孕妇的血浆和红细胞中的游离和总丙二醛（MDA），超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPX）以及维生素A和E进行了测定。其中，27例患有糖尿病的糖尿病患者包括妊娠糖尿病（I型）或先前患有胰岛素依赖型糖尿病（1型糖尿病）的II组。其余27例为对照。确定所有妇女的空腹血糖和HbA（1c）水平。结果：所有糖尿病妇女和两个亚组中的HbA（1c）水平，无血浆和无红细胞的MDA水平均显着高于对照组。在所有糖尿病妇女中，血浆维生素E和红细胞维生素A水平显着低于对照组。此外，所有糖尿病女性，各亚组的GPX和仅1型糖尿病的SOD的GPX和SOD活性均显着降低。结论：我们应监测先前患有1型糖尿病或GDM的孕妇所表现出的氧化应激增加。通过严格控制怀孕期间的血糖并提出严格的建议，也许还补充抗氧化剂。

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