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首页> 外文期刊>Clinical Biochemistry >Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.
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Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.

机译：随着年龄的增长，同型半胱氨酸和新蝶呤的产量增加，色氨酸降解。

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Objectives: Aging is associated with an increased frequency of abnormal immune system function, which may cause infections, autoimmune diseases, and cardiovascular or neurodegenerative disorders. Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. Homocysteine is known to be elevated in the elderly, which is possibly due to an insufficient availability of folate, B(6), and/or B(12). Design and Methods: Serum concentrations of neopterin, homocysteine, tryptophan and kynurenine, and of vitamins folate and B(12) were measured in 43 healthy individuals (21 females, 22 males) aged 34-93 years. The ratio of the concentration of the product of IDO, kynurenine, versus the substrate tryptophan (kyn/trp) was calculated to estimate IDO activity. Results: Comparing three age groups of similar size (34-60, 61-71, and 72-93 years), neopterin and homocysteine concentrations as well as the kyn/trp ratio were found to increase with older age (all P < 0.01). Folate concentrations were lower in the middle-aged group as compared with the other two subgroups of individuals. Vitamin B(12) concentrations did not differ between groups. Positive correlations were found between kyn/trp and neopterin and homocysteine concentrations (all P < 0.01). Conclusions: Increasing neopterin concentrations and kyn/trp with older age are in line with the view that aging in healthy people is associated with immune activation especially of the T-cell/macrophage system.
机译：目的：衰老与免疫系统功能异常的频率增加有关，这可能导致感染，自身免疫性疾病以及心血管或神经退行性疾病。 Th1型细胞因子干扰素-γ（IFN-γ）通过吲哚胺（2,3）-双加氧酶（IDO）诱导新蝶呤的产生以及色氨酸的降解，对这些生物化学变化的定量分析可以监测免疫系统的激活。已知同型半胱氨酸在老年人中升高，这可能是由于叶酸，B（6）和/或B（12）的可用性不足所致。设计与方法：对年龄在34-93岁的43位健康个体（21位女性，22位男性）中的新蝶呤，高半胱氨酸，色氨酸和犬尿氨酸以及维生素叶酸和B（12）的血清浓度进行了测量。计算IDO产物犬尿氨酸的浓度与底物色氨酸的浓度之比（kyn / trp），以估计IDO活性。结果：比较三个年龄相似的年龄组（34-60、61-71和72-93岁），发现新蝶呤和同型半胱氨酸浓度以及kyn / trp比值随年龄的增加而增加（所有P <0.01） 。与其他两个亚组相比，中年组的叶酸浓度较低。两组之间的维生素B（12）浓度没有差异。发现kyn / trp与新蝶呤和同型半胱氨酸浓度之间呈正相关（所有P <0.01）。结论：随着年龄的增长，新蝶呤的浓度和kyn / trp的增加与健康人的衰老与免疫激活特别是T细胞/巨噬细胞系统的免疫激活有关。

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