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首页> 外文期刊>Clinical Biochemistry >The potential clinical utility of serial plasma albumin mRNA monitoring for the post-liver transplantation management
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The potential clinical utility of serial plasma albumin mRNA monitoring for the post-liver transplantation management

机译：串行血浆白蛋白mRNA监测在肝移植后管理中的潜在临床应用

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Objectives: Elevated albumin (ALB) mRNA concentration has been reported in the plasma of patients with liver diseases. The plasma ALB mRNA measurement was shown to be an effective indicator of liver pathologies with superior diagnostic sensitivity and specificity when compared with alanine transaminase (ALT). We hypothesized that serial plasma ALB mRNA analysis would be helpful in the early detection and monitoring of post-liver transplantation complications. Design and methods: One hundred and five blood specimens were collected from 24 post-transplant recipients. Biochemical liver function test profiles and plasma ALB mRNA concentrations were assessed. Results: Over the study period, the health status of 14 recipients (58%) remained stable (Stable group). Their plasma ALB mRNA concentrations remained within a low-concentration range. In contrast, 10 recipients (42%) developed 14 episodes of hepatic complications (Unstable group). The median plasma ALB mRNA concentration of the Unstable group was 6.5-times higher than that of the Stable group. Plasma ALB mRNA concentration was elevated on 13/14 (93%) episodes of the hepatic complications while ALT was elevated only on 8/14 (57%) episodes. Conclusions: The elevation of plasma ALB mRNA may allow sensitive detection of hepatic complications and monitoring of the clinical course in a dynamic fashion. Serial plasma ALB mRNA measurement is potentially useful for post-liver transplantation management.
机译：目的：已报道肝病患者血浆中白蛋白（ALB）mRNA浓度升高。与丙氨酸转氨酶（ALT）相比，血浆ALB mRNA的测量被证明是肝脏病理学的有效指标，具有优越的诊断敏感性和特异性。我们假设串行血浆ALB mRNA分析将有助于早期检测和监测肝移植后并发症。设计与方法：从24位移植后的接受者中收集了105个血液样本。评估生化肝功能测试概况和血浆ALB mRNA浓度。结果：在研究期间，14位接受者（58％）的健康状况保持稳定（稳定组）。他们的血浆ALB mRNA浓度保持在低浓度范围内。相反，有10位接受者（42％）发生了14次肝并发症（不稳定组）。不稳定组的血浆ALB mRNA浓度中位数比稳定组高6.5倍。肝并发症的13/14（93％）发作时血浆ALB mRNA浓度升高，而ALT仅在8/14（57％）发作时升高。结论：血浆ALB mRNA的升高可允许以动态方式灵敏地检测肝并发症并监测临床过程。串行血浆ALB mRNA测量可能对肝后移植管理有用。

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