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首页> 外文期刊>Clinical Biochemistry >Activation of serum aminotransferases by pyridoxal-5'-phosphate in epileptic patients treated with anticonvulsant drugs.
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Activation of serum aminotransferases by pyridoxal-5'-phosphate in epileptic patients treated with anticonvulsant drugs.

机译：抗癫痫药治疗的癫痫患者的5'-磷酸吡ido醛激活了血清氨基转移酶。

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Objectives: Significant decreases in the serum concentration of pyridoxal-5'-phosphate (PLP) have been described in epileptic patients treated with anticonvulsant drugs. This would be expected to lead to a decrease in the sensitivity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) for the detection of hepatocellular damage in these patients if optimized methods with coenzyme supplementation are not used. The aim of our study was to evaluate this hypothesis. Design and Methods: The serum activities of AST and ALT (with and without the addition of PLP) were determined in a group of 90 adult epileptic patients (56 male, 34 female) undergoing chronic treatment polytherapy with phenobarbital, phenytoin, carbamazepine, and valproic acid. As a control group, 49 clinically healthy individuals were studied with a similar distribution for age and sex. Results: Supplementation with PLP produced an activation of AST and ALT in both the control and patient groups with a highly significant correlation between the enzyme activities with and without the addition of PLP (r >/= 0.956, P < 0.001). The differences between the control and patient groups for the PLP activation of both aminotransferases were not clinically significant. The increases in AST (9%) and ALT (28%) in the patient group compared to the control group were lower than those found for alcohol dehydrogenase (ADH, 82%) and alpha-glutathione S-transferase (alphaGST, 76%). Conclusions: It does not appear that in the epileptic patients studied the in vitro addition of PLP increased the diagnostic sensitivity of AST and ALT for hepatocellular injury. The lower responses of both aminotransferases to the action of anticonvulsant drugs in relation to other cytosolic enzymes may be due to the preferred periportal localization of AST and ALT in the hepatic lobe.
机译：目的：已报道抗惊厥药物治疗的癫痫患者血清吡ido醛-5'-磷酸（PLP）的血清浓度显着降低。如果不使用补充辅酶的优化方法，这将导致这些患者检测天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的敏感性降低。我们研究的目的是评估这一假设。设计与方法：在一组90例接受苯巴比妥，苯妥英钠，卡马西平和丙戊酸慢性治疗的成人癫痫患者（56例男性，34例女性）中测定了AST和ALT的血清活性（有无PLP）。酸。作为对照组，研究了49位临床健康个体，其年龄和性别分布相似。结果：在对照组和患者组中，补充PLP均会激活AST和ALT，在添加和不添加PLP的情况下，酶活性之间都具有非常显着的相关性（r> / = 0.956，P <0.001）。对照组和患者组之间两种氨基转移酶的PLP激活差异均无临床意义。与对照组相比，患者组中AST（9％）和ALT（28％）的升高低于酒精脱氢酶（ADH，82％）和α-谷胱甘肽S-转移酶（alphaGST，76％）的升高。 。结论：在癫痫患者研究中似乎没有发现体外添加PLP可以提高AST和ALT对肝细胞损伤的诊断敏感性。相对于其他胞质酶，这两种转氨酶对抗惊厥药作用的较低反应可能是由于肝叶中AST和ALT的优选门静脉局部定位所致。

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