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首页> 外文期刊>Clinical biomechanics >Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament.
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Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament.

机译：骨髓出血可增强原位冻融的前交叉韧带的重塑。

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BACKGROUND: The purpose of this study is to biomechanically and histologically evaluate the effect of bleeding from bone marrow on remodeling of the in situ frozen-thawed anterior cruciate ligament. METHODS: Forty-four rabbits were used. Eight rabbits were used to evaluate the amount of bleeding at days 1-4. Thirty-six rabbits were divided into two groups, after the right anterior cruciate ligament underwent the freeze-thaw treatment. In Group I, no treatments were applied. In Group II, a tunnel was drilled into the bone marrow the femoral intercondylar notch. Each rabbit was sacrificed at 6 or 12 weeks. We examined the mechanical properties, and the histology of the anterior cruciate ligament. FINDINGS: A small amount of blood clot was observed only on the first day in Group I, while a large amount of blood clot was seen around the anterior cruciate ligament for 3 days after surgery in Group II. In the midsubstance, a number of cells were scattered in Group II, no cells were seen in Group I at 6 weeks. The tangent modulus showed some tendency of difference between Groups I and II at each period. INTERPRETATION: Bleeding from the bone marrow obviously enhanced extrinsic cell infiltration into the in situ frozen-thawed anterior cruciate ligament at 6 weeks, and showed some effects on its mechanical properties. This study implied that, in anterior cruciate ligament reconstruction, the blood from a bone tunnel play an important role in graft remodeling.
机译：背景：这项研究的目的是生物力学和组织学评估骨髓出血对原位冷冻解冻的前交叉韧带重塑的影响。方法：使用44只兔子。在第1-4天使用八只兔子评估出血量。右前交叉韧带冻融后，将36只兔分为两组。在第一组中，未进行任何治疗。在第二组中，在股骨con间凹处钻入一个隧道。在6或12周处死每只兔子。我们检查了前交叉韧带的机械性能和组织学。结果：仅在第一组的第一天观察到少量血块，而在第二组的术后三天，在前十字韧带周围观察到大量的血块。在中间物质中，第II组中散布了许多细胞，第6周时在I组中未见任何细胞。切线模量在每个时期在I组和II组之间表现出一定的差异趋势。解释：6周时，骨髓出血明显增强了外源性细胞向原位冻融的前交叉韧带的浸润，并对其力学性能产生了一定影响。这项研究表明，在前十字韧带重建中，来自骨隧道的血液在移植物重塑中起重要作用。

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