...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Comparative Physiology, B. Biochemical, Systemic, and Environmental Physiology >Effects of seasonal and latitudinal cold on oxidative stress parameters and activation of hypoxia inducible factor (HIF-1) in zoarcid fish
【24h】

Effects of seasonal and latitudinal cold on oxidative stress parameters and activation of hypoxia inducible factor (HIF-1) in zoarcid fish

机译：季节性和纬度寒冷对斑鱼氧化应激参数和缺氧诱导因子（HIF-1）活化的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute, short term cooling of North Sea eelpout Zoarces viviparus is associated with a reduction of tissue redox state and activation of hypoxia inducible factor (HIF-1) in the liver. The present study explores the response of HIF-1 to seasonal cold in Zoarces viviparus, and to latitudinal cold by comparing the eurythermal North Sea fish to stenothermal Antarctic eelpout (Pachycara brachycephalum). Hypoxic signalling (HIF-1 DNA binding activity) was studied in liver of summer and winter North Sea eelpout as well as of Antarctic eelpout at habitat temperature of 0 degrees C and after long-term warming to 5 degrees C. Biochemical parameters like tissue iron content, glutathione redox ratio, and oxidative stress indicators were analyzed to see whether the cellular redox state or reactive oxygen species formation and HIF activation in the fish correlate. HIF-1 DNA binding activity was significantly higher at cold temperature, both in the interspecific comparison, polar vs. temperate species, and when comparing winter and summer North Sea eelpout. Compared at the low acclimation temperatures (0 degrees C for the polar and 6 degrees C for the temperate eelpout) the polar fish showed lower levels of lipid peroxidation although the liver microsomal fraction turned out to be more susceptible to lipid radical formation. The level of radical scavenger, glutathione, was twofold higher in polar than in North Sea eelpout and also oxidised to over 50%. Under both conditions of cold exposure, latitudinal cold in the Antarctic and seasonal cold in the North Sea eelpout, the glutathione redox ratio was more oxidised when compared to the warmer condition. However, oxidative damage parameters (protein carbonyls and thiobarbituric acid reactive substances (TBARS) were elevated only during seasonal cold exposure in Z. viviparus. Obviously, Antarctic eelpout are keeping oxidative defence mechanisms high enough to avoid accumulation of oxidative damage products at low habitat temperature. The paper discusses how HIF could be instrumental in cold adaptation in fish.
机译：北海海藻的短期急性降温与肝脏组织氧化还原状态的降低和缺氧诱导因子（HIF-1）的激活有关。本研究通过比较极热的北海鱼类与南极的嗜热喷发（Pachycara brachycephalum），探讨了HIF-1对小带虫Zoarces viviparus的季节性寒冷以及对纬度寒冷的反应。在夏季栖息地温度为0摄氏度并长期升温至5摄氏度后，研究了夏季和冬季北海海藻和南极海藻的肝脏中的低氧信号传导（HIF-1 DNA结合活性）。生化参数，如组织铁含量，谷胱甘肽氧化还原比和氧化应激指标进行了分析，以查看鱼中细胞氧化还原状态或活性氧的形成与HIF活化是否相关。 HIF-1 DNA结合活性在低温下，无论是在种间比较，极地还是温带物种中，以及在比较冬季和夏季北海出水时，都具有较高的优势。与在低适应温度下（极地为0摄氏度，温带出水为6摄氏度）相比，极地鱼类显示出较低的脂质过氧化水平，尽管事实证明肝脏微粒体部分对脂质自由基的形成更敏感。自由基清除剂谷胱甘肽的水平在极性上比北海出水高出两倍，并且被氧化至50％以上。在较冷的条件下，南极纬度的寒冷和北海出水口的季节性寒冷下，与较温暖的条件相比，谷胱甘肽氧化还原比的氧化程度更高。然而，氧化应激参数（蛋白质羰基和硫代巴比妥酸反应性物质（TBARS）仅在Z. viviparus的季节性冷暴露期间才升高。显然，南极溢流使氧化防御机制保持足够高的水平，从而避免了在低栖息地温度下氧化损伤产物的积累。本文讨论了HIF如何在鱼类的冷适应中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号