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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury.
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Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury.

机译：烟碱型乙酰胆碱受体激活剂多奈哌齐对脑震荡轻度脑损伤大鼠的神经保护和抗记忆删除作用。

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摘要

In this study we evaluated the effect of donepezil on the neurodegeneration and behavioral impairments induced by mild traumatic brain injury (MTBI). Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. Donepezil was given orally to rats subjected to MTBI. Treatment with a single oral dose of donepezil (12mg/kg) immediately after injury significantly attenuated MTBI-induced neuronal death and cognitive impairment as measured by preservation of neurons in the CA1 region of the hippocampus and a water maze test respectively. However, these neuroprotective effects were prevented by concomitant injection of mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection is mediated by nAChR activation.
机译：在这项研究中，我们评估了多奈哌齐对轻度颅脑损伤（MTBI）引起的神经变性和行为障碍的影响。多奈哌齐是一种乙酰胆碱酯酶抑制剂，用于治疗阿尔茨海默氏病。多奈哌齐口服给予MTBI的大鼠。损伤后立即单次口服多奈哌齐（12mg / kg）进行治疗，可显着减轻MTBI诱导的神经元死亡和认知障碍，这通过分别将海马CA1区神经元保存和水迷宫测试来衡量。但是，这些神经保护作用可通过同时注射美卡敏（一种烟碱乙酰胆碱受体（nAChR）拮抗剂）来预防，表明该保护作用是由nAChR激活介导的。

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