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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand.
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Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand.

机译：新西兰奥克兰市医院的结核性脑膜炎的神经和全身并发症及其治疗。

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摘要

Mortality and serious long-term sequelae still occur in about 50% of patients with tuberculous meningitis. The frequency and the clinical features of neurological and systemic complications were determined in a retrospective review of 104 patients with tuberculous meningitis. Complications occurred in 81 patients (78%). The most common complications were: hyponatraemia 49%, hydrocephalus 42%, stroke 33%, cranial nerve palsies 29%, epileptic seizures 28%, diabetes insipidus 6%, tuberculoma 3%, myeloradiculopathy 3% and hypothalamic syndrome 3%. The most common iatrogenic complication was hepatotoxicity related to anti-tuberculosis treatment in seven patients. Twenty-three patients (22%) died. At last follow-up one patient (1%) remained in a persistent vegetative state, 14 patients (13%) had severe disability and 12 patients (12%) were moderately disabled. The most common complications in the 81 long-term survivors were cognitive impairment (12%) and epilepsy (11%). Neurological and systemic complications of tuberculous meningitis were common and were important causes of mortality and long-term morbidity.
机译：约50％的结核性脑膜炎患者仍会发生死亡率和严重的长期后遗症。回顾性分析104例结核性脑膜炎患者的神经系统和全身并发症的发生频率及临床特征。 81例患者发生并发症（78％）。最常见的并发症是：低钠血症49％，脑积水42％，中风33％，颅神经麻痹29％，癫痫性癫痫发作28％，尿崩症6％，结核瘤3％，脊髓神经根病3％和下丘脑综合征3％。最常见的医源性并发症是与抗结核治疗相关的肝毒性，共有7例患者。 23例患者（占22％）死亡。在最后一次随访中，一名患者（1％）保持为植物人持续状态，严重残疾的患者有14名（13％），中度残疾的有12名（12％）。在81位长期幸存者中，最常见的并发症是认知障碍（12％）和癫痫病（11％）。结核性脑膜炎的神经系统疾病和全身并发症很常见，并且是导致死亡和长期发病的重要原因。

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