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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease
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Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease

机译：脑源性神经营养因子/原肌球蛋白相关激酶B（BDNF / TrkB）信号在阿尔茨海默氏病中的作用

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摘要

Alzheimer's disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Aβ) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin- related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Aβ, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention.
机译：阿尔茨海默氏病（AD）是老年人痴呆症的最常见原因之一。其特征在于神经毒性肽淀粉样蛋白（Aβ）肽原纤维的细胞外沉积，并伴有受影响个体大脑中神经元的大量丢失。但是，AD的发病机理尚未完全了解。这篇综述的目的是讨论脑源性神经营养因子（BDNF）/原肌球蛋白相关激酶B（TrkB）信号在AD发生中的可能作用，重点是BDNF / TrkB信号在Aβ产生，tau过度磷酸化中的作用。和认知下降，并探索AD干预的新可能性。

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