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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Immunohistochemical study of the extracellular matrix proteins laminin, fibronectin and type IV collagen in secretory meningiomas.
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Immunohistochemical study of the extracellular matrix proteins laminin, fibronectin and type IV collagen in secretory meningiomas.

机译：分泌性脑膜瘤细胞外基质蛋白层粘连蛋白，纤连蛋白和IV型胶原的免疫组织化学研究。

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摘要

The extracellular matrix plays a pivotal role in numerous cellular functions during normal and pathological processes. Secretory meningiomas are rare histological meningioma subtypes that have benign behavior, are highly vascularized and are frequently accompanied by massive peritumoral edema. The aim of this study was to assess in secretory meningiomas the immunohistochemical expression of laminin, fibronectin and type IV collagen, proteins found in the extracellular matrix. Extracellular matrix proteins were evaluated in samples from six secretory meningiomas using a semiquantitative scale ranging from not detected (0) to marked (3). Laminin expression was not detected in two cases, but was minimal in one, moderate in one and marked in the remaining cases. Fibronectin expression was absent in two cases, minimal in two, moderate in one and marked with generalized distribution in the remaining case. Type IV collagen expression was minimal in three cases, moderate in two and marked with generalized distribution in the remaining case. Our results are indicative of significant neoangiogenic activity. Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix.
机译：在正常和病理过程中，细胞外基质在众多细胞功能中起关键作用。分泌性脑膜瘤是罕见的组织学性脑膜瘤亚型，具有良性行为，高度血管化并经常伴有大量瘤周水肿。这项研究的目的是评估分泌型脑膜瘤中层粘连蛋白，纤连蛋白和IV型胶原蛋白（在细胞外基质中发现）的免疫组织化学表达。使用从未检测到（0）到标记（3）的半定量量表评估了六个分泌性脑膜瘤样品中的细胞外基质蛋白。在两例中均未检测到层粘连蛋白表达，但在其中一例中检测到层粘连蛋白表达最低，在中一例中检测到层粘连蛋白表达，在其余情况下均显着。纤连蛋白的表达在两种情况下均不存在，在两种情况中最低，在一种情况中中度，在其余情况下具有普遍分布。 IV型胶原蛋白的表达在3例中最小，在2例中，在其余情况下具有普遍分布。我们的结果表明显着的新血管生成活性。脑膜瘤的大小通过增加细胞外基质的产生而增加;此外，通常与瘤形成相关的细胞的增殖需要与细胞外基质的大量相互作用。

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