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Brain MRI abnormalities in Brazilian patients with neuromyelitis optica

机译:巴西视神经脊髓炎患者的脑部MRI异常

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Brain abnormalities in neuromyelitis optica (NMO) have been reported previously, but the pathophysiological mechanism and clinical relevance of these abnormalities are poorly understood. We assessed the prevalence and patterns of brain MRI abnormalities in a Brazilian cohort of patients with NMO. Conventional brain MRI and medical records from 24 Brazilian patients with NMO were retrospectively evaluated. Brain MRI were classified into four subgroups: normal, non-specific lesions, multiple sclerosis (MS)-like lesions, and typical lesions. Brain lesions were detected in 19 patients (79.2%). Fourteen patients (58.3%) had non-specific lesions, three (12.5%) had MS-like lesions, and two (8.3%) had typical lesions. Differences between these subgroups with respect to the Expanded Disability Status Scale (EDSS) scores (p = 0.86) were not significant. This study demonstrates a high prevalence of brain abnormalities in Brazilian patients with NMO; however, we did not find a significant relationship between these abnormalities and EDSS scores.
机译:先前已报道了视神经脊髓炎(NMO)的脑部异常,但对这些异常的病理生理机制和临床相关性了解甚少。我们评估了巴西NMO患者队列中MRI患病率和模式。回顾性评估了来自24名巴西NMO患者的常规脑MRI和医疗记录。脑MRI分为四个亚组:正常,非特异性病变,多发性硬化(MS)样病变和典型病变。在19例患者中发现了脑部病变(79.2%)。 14位患者(58.3%)有非特异性病变,三位(12.5%)具有MS样病变,两位(8.3%)具有典型病变。这些亚组之间在扩展残疾状况量表(EDSS)评分方面的差异(p = 0.86)并不显着。这项研究表明巴西NMO患者脑部异常的发生率很高。但是,我们没有发现这些异常与EDSS评分之间存在显着关系。

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