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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Risk factors for increased multiple sclerosis susceptibility in the Iranian population
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Risk factors for increased multiple sclerosis susceptibility in the Iranian population

机译：伊朗人群中多发性硬化症易感性增加的危险因素

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摘要

Multiple sclerosis (MS) is a complex autoimmune disease with increasing prevalence. Many factors have been assessed in relation to its development and its worldwide geographical and racial distribution. Therefore, we decided to conduct a nationwide case-control matched study to estimate the possible influence of putative risk factors on MS status in an Iranian MS population. Between January 2008 and September 2013, 1403 patients diagnosed with MS according to the Poser or McDonald criteria and 883 controls were studied. Of all patients, there were 921 women and 296 men (ratio 3.1:1) with a mean age of 32.6 +/- 8.7 years. In the multivariate model adjusted for sex and age (+/- 2 years), we found associated risk factors of MS to be: history of any allergic condition (Odds ratio (OR): 1.92, 95% Confidence interval (CI): 1.55-2.47, p <0.001), and smoking (OR: 1.93, 95% Cl: 1.31-2.73, p <0.001). Sunlight exposure 3 hours was found to be associated with a reduced risk of MS (OR: 0.23, 95% CI: 0.15-0.31, p < 0.001). As expected, cases were more likely to have a positive family history of MS than controls (OR: 1.91, 95% Cl: 1.33-2.75, p <0.001). A significant association was found between family history of other autoimmune diseases and MS risk (OR: 1.57, 95% CI: 1.18-2.09, p = 0.002). These results support the hypothesis that sun exposure is associated with a decreased risk of MS while smoking, autoimmune family history, MS family history, and personal allergy history are risk factors for MS susceptibility. (C) 2014 Elsevier Ltd. All rights reserved.
机译：多发性硬化症（MS）是一种复杂的自身免疫性疾病，患病率不断上升。关于其发展及其全球地理和种族分布，已经评估了许多因素。因此，我们决定进行一项全国病例对照研究，以估计推定的危险因素对伊朗MS人群MS状况的可能影响。在2008年1月至2013年9月之间，研究了根据Poser或McDonald标准诊断为MS的1403名患者和883名对照。在所有患者中，有921名女性和296名男性（比率3.1：1），平均年龄为32.6 +/- 8.7岁。在针对性别和年龄（+/- 2岁）进行调整的多元模型中，我们发现MS的相关危险因素为：任何过敏性疾病的病史（几率（OR）：1.92，95％可信区间（CI）：1.55） -2.47，p <0.001）和吸烟（OR：1.93，95％Cl：1.31-2.73，p <0.001）。发现3小时的日光照射与MS风险降低相关（OR：0.23，95％CI：0.15-0.31，p <0.001）。不出所料，与对照组相比，病例更可能具有阳性的MS家族史（OR：1.91，95％Cl：1.33-2.75，p <0.001）。在其他自身免疫性疾病的家族史和MS风险之间发现显着相关性（OR：1.57，95％CI：1.18-2.09，p = 0.002）。这些结果支持以下假设：阳光照射与吸烟中MS风险降低相关，自身免疫家族史，MS家族史和个人过敏史是MS易感性的危险因素。 （C）2014 Elsevier Ltd.保留所有权利。

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