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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: Characterization of differential expression patterns in cerebral vasospasm
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Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: Characterization of differential expression patterns in cerebral vasospasm

机译：动脉瘤性蛛网膜下腔出血后的多重蛋白谱分析：脑血管痉挛中差异表达模式的表征

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摘要

Cerebral vasospasm is a major contributor to delayed morbidity following aneurysmal subarachnoid hemorrhage. We sought to evaluate differential plasma protein levels across time in patients with aneurysmal subarachnoid hemorrhage to identify potential biomarkers and to better understand the pathogenesis of cerebral vasospasm. Nine female patients with aneurysmal subarachnoid hemorrhage underwent serial analysis of 239 different serum protein levels using quantitative, multiplexed immunoassays (Discovery-MAP 250+ v2.0, Myriad RBM, Austin, TX, USA) on post-hemorrhage days 0 and 5. A repeated measures analysis of variance determined that mean protein concentration decreased significantly in patients who developed vasospasm versus those who did not for alpha-2-macroglobulin (F [1.00,7.00] =16.33, p = 0.005), angiogenin (F [1.00,7.00] = 7.65, p = 0.028), apolipoprotein A-IV (F [1.00,7.00] =6.308, p = 0.040), granulocyte colony-stimulating factor (F [1.00,7.00] = 9.08, p = 0.020), macrophage-stimulating protein (F [1.00,7.00] = 24.21, p = 0.002), tetranectin (F [1.00,7.00] = 5.46, p < 0.039), vascular endothelial growth factor receptor 3 (F [1.00,7.00] = 6.94, p = 0.034), and significantly increased for vitronectin (F [1.00,7.00] = 5.79, p = 0.047). These biomarkers may be of value in detecting cerebral vasospasm, possibly aiding in the identification of patients at high-risk prior to neurological deterioration. (C) 2014 Elsevier Ltd. All rights reserved.
机译：脑血管痉挛是导致动脉瘤性蛛网膜下腔出血后延迟发病的主要因素。我们试图评估动脉瘤性蛛网膜下腔出血患者不同时间血浆蛋白水平的差异，以鉴定潜在的生物标志物并更好地了解脑血管痉挛的发病机制。 9名患有动脉瘤性蛛网膜下腔出血的女性患者在出血后第0天和第5天接受了定量，多重免疫分析（Discovery-MAP 250+ v2.0，Myriad RBM，奥斯汀，德克萨斯州，美国），对239种不同的血清蛋白水平进行了系列分析。重复测量方差分析确定，发生血管痉挛的患者与未接受α-2-巨球蛋白的患者（F [1.00,7.00] = 16.33，p = 0.005），血管生成素（F [1.00,7.00] ] = 7.65，p = 0.028），载脂蛋白A-IV（F [1.00,7.00] = 6.308，p = 0.040），粒细胞集落刺激因子（F [1.00,7.00] = 9.08，p = 0.020），巨噬细胞-刺激蛋白（F [1.00,7.00] = 24.21，p = 0.002），四连蛋白（F [1.00,7.00] = 5.46，p <0.039），血管内皮生长因子受体3（F [1.00,7.00] = 6.94，p = 0.034），而玻连蛋白显着增加（F [1.00,7.00] = 5.79，p = 0.047）。这些生物标志物在检测脑血管痉挛中可能具有价值，可能有助于识别神经系统恶化之前处于高风险的患者。 （C）2014 Elsevier Ltd.保留所有权利。

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