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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy
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Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy

机译：压缩性脊髓病症状急剧恶化的患者的脑脊液中磷酸化的神经丝亚单位NF-H升高

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It is known that the severity of compression myelopathy sometimes worsens rapidly and results in poor functional recovery because of limited axonal regeneration. Levels of phosphorylated neurofilament subunit NF-H (pNF-H), which indicate axonal degeneration, are elevated in other neurological disorders. To our knowledge, there has been no examination of pNF-H levels in compression myelopathy. Therefore, we conducted a pilot cross-sectional study to evaluate pNF-H levels in the cerebrospinal fluid (CSF) of patients with worsening symptoms of cervical compression myelopathy. From January 2011 to March 2013, 51 samples of CSF were collected from patients at the time of myelography before spinal surgery. The indications for surgery were acutely worsening compression myelopathy (AM) in eight, chronic compression myelopathy (CM) in six, and lumbar canal stenosis (LCS) in 37 patients. The pNF-H levels were measured using a standard enzyme-linked immunosorbent assay. The mean +/- standard deviation pNF-H value was 2127.1 +/- 556.8 pg/ml in AM patients, 175.8 +/- 67.38 pg/ml in CM patients and 518.7 +/- 665.7 pg/ml in LCS patients. A significant increase in pNF-H levels was detected in the CSF of patients with AM compared with those with either CM or LCS. The clinical outcome of surgical treatment for patients with cervical myelopathy was satisfactory in both AM and CM patients. Despite the limitations of small sample size and lack of healthy CSF control data due to ethical considerations, our results suggest that pNF-H in CSF can act as a biomarker that reflects the severity of AM. (C) 2014 Published by Elsevier Ltd.
机译：众所周知，由于轴突再生受限，压迫性脊髓病的严重程度有时会迅速恶化，并导致功能恢复较差。在其他神经系统疾病中，表明轴突变性的磷酸化神经丝亚单位NF-H（pNF-H）水平升高。据我们所知，还没有检查压迫性脊髓病中pNF-H的水平。因此，我们进行了一项初步的横断面研究，以评估颈椎压缩性脊髓病症状恶化的患者脑脊液（CSF）中的pNF-H水平。从2011年1月至2013年3月，在进行脊柱手术前的脊髓造影时，从患者中收集了51例CSF样本。手术的指征是急性压迫性脊髓病（AM）恶化的8名，慢性压迫性脊髓病（CM）的恶化的6名和腰椎管狭窄（LCS）的37例。使用标准的酶联免疫吸附测定法测量pNF-H水平。 AM患者的平均+/-标准偏差pNF-H值为2127.1 +/- 556.8 pg / ml，CM患者为175.8 +/- 67.38 pg / ml，LCS患者为518.7 +/- 665.7 pg / ml。与CM或LCS患者相比，AM患者的CSF中pNF-H水平显着升高。颈椎病患者的外科治疗的临床结果在AM和CM患者中均令人满意。尽管出于道德方面的考虑，尽管样本量小且缺乏健康的CSF对照数据，但我们的结果表明，CSF中的pNF-H可以作为反映AM严重程度的生物标志物。 （C）2014由Elsevier Ltd.出版

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