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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population
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Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population

机译：在健康的中国人群中，阿尔茨海默氏症相关的尿神经元线蛋白水平随年龄增加

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Alzheimer-associated neuronal thread protein (AD7c-NTP) has been found to be a biomarker for Alzheimer's disease (AD) with elevated levels in the cerebrospinal fluid and urine from AD patients in the early stage of the disease. Whether the urine level of AD7c-NTP in healthy people is age-related is still unclear. We aimed to measure the level of urine AD7c-NTP in a healthy Chinese population of different ages. Urine samples of 294 subjects were collected from the Department of Health Examination Center at Xuanwu Hospital of Capital Medical University, China. The samples were divided into five groups by age: Group 1 (20-29 years), Group 2 (30-39 years), Group 3 (40-49 years), Group 4 (50-59 years) and Group 5 ( >= 60 years). The Mini Mental State Examination and Montreal Cognitive Assessment were carried out. The level of AD7c-NTP in the urine specimen was detected by enzyme-linked immunosorbent assay. The urine AD7c-NTP levels in Group 1, 2, 3, 4 and 5 were 0.3012 +/- 0.2373, 0.3702 +/- 0.2422, 0.3914 +/- 0.2442, 0.4844 +/- 0.2908 and 0.5880 +/- 0.2638 ng/ml (mean +/- standard error of the mean), respectively. The urine AD7c-NTP levels among the five groups differed significantly (F = 6.181, p = 0.00). Females had a higher urine AD7c-NTP content than males, and the urine AD7c-NTP level increased with age (r = 0.28, p = 0.00). To our knowledge this study is the first to show that urine AD7c-NTP level increases with age in a healthy Chinese population without cognitive dysfunction. This study suggests that different cut-off values aimed at different age groups should be established for diagnosing cognitive impairments in clinical practice. (C) 2014 Elsevier Ltd. All rights reserved.
机译：已发现与阿尔茨海默氏症相关的神经元线蛋白（AD7c-NTP）是阿尔茨海默氏病（AD）的生物标志物，在疾病早期，其脑脊液和尿液水平升高。尚不清楚健康人群中AD7c-NTP的尿液水平是否与年龄有关。我们旨在测量健康的不同年龄人群的尿液AD7c-NTP水平。从首都医科大学宣武医院体检中心收集了294名受试者的尿液样本。样本按年龄分为五组：第一组（20-29岁），第二组（30-39岁），第三​​组（40-49岁），第四组（50-59岁）和第五组（> = 60年）。进行了迷你心理状态检查和蒙特利尔认知评估。用酶联免疫吸附法检测尿液中AD7c-NTP的水平。第1、2、3、4和5组的尿AD7c-NTP水平为0.3012 +/- 0.2373、0.3702 +/- 0.2422、0.3914 +/- 0.2442、0.4844 +/- 0.2908和0.5880 +/- 0.2638 ng / ml （平均值的平均值+/-标准误差）。五组之间的尿AD7c-NTP水平差异显着（F = 6.181，p = 0.00）。女性的尿液AD7c-NTP含量高于男性，且尿液AD7c-NTP水平随年龄增加而增加（r = 0.28，p = 0.00）。据我们所知，该研究是第一个显示在没有认知功能障碍的健康中国人群中尿中AD7c-NTP水平随年龄增加而增加的研究。这项研究表明，应针对不同年龄组建立不同的临界值，以在临床实践中诊断认知障碍。 （C）2014 Elsevier Ltd.保留所有权利。

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